Organic Chemistry Seminar, Dr. Eugene Chen (Colorado State University)

Mon, 2017-09-11 12:00 - 13:00
Speaker: 
Host: Walsh
Location: 

Carol Hoff Lynch Lecture Hall Chemistry Complex

Attached Document: 

Title : Metal- and Organocatalyzed Synthesis of Recyclable Polymers for a Circular Materials Economy

 

Physical Chemistry Seminar Dr. Jahan Dawlaty ( University of Southern California)

Wed, 2017-08-16 13:00 - 14:00
Location: 

Carol Lynch Lecture Hall, Chemistry Complex

Attached Document: 

Title: Proton Dynamics in the Excited States: From Model Systems to Applications

 

Inorganic Chemistry Seminar Dr. Dave Harris ( Northwestern University)

Tue, 2018-04-03 12:00 - 13:00
Speaker: 
Host: Tomson
Location: 
Carol Lynch Lecture Hall, Chemistry Complex

Inorganic Chemistry Seminar Dr. Mark Antonio (Argonne National Laboratory)

Tue, 2018-02-06 12:00 - 13:00
Speaker: 
Host:Tomson
Location: 
Carol Lynch Lecture Hall, Chemistry Complex

Physical Chemistry Seminar, Dr. Lutz Maibaum (University of Washington, Seattle)

Thu, 2017-09-14 13:00 - 14:00
Speaker: 
Host:Subotnik
Location: 
Carol Lynch Lecture Hall, Chemistry Complex

Title Spatial organization of the plasma membrane and peripheral membrane proteins

Carol Hartranft

Photo: 
First Name: 
Carol
Last Name: 
Hartranft
Official Title: 
Administrative Assistant
Contact Information
Office Location: 
124A
Email: 
hartranc@sas.upenn.edu
Phone: 
215-898-8317

Physical Chemistry Seminar Dr. Thomas Rizzo (École Polytechnique Fédérale de Lausanne)

Thu, 2017-10-12 13:00 - 14:00
Speaker: 

 

Host Lester

Title Cryogenic spectroscopy of biomolecular ions: From homo-chiral selection to carbohydrate analysis

 

Abstract While mass spectrometry (MS) has been a workhorse tool for the detection and identification of biological molecules, it is limited in its ability to determine 3-dimensional structure. When MS is combined with ion mobility spectrometry (IMS), which determines the orientationally averaged cross section of ions as they are dragged through a static gas, one gains valuable information on the molecular shape, albeit not the precise 3-D structure. On the other hand, adding a vibrational spectroscopic dimension to MS provides a fingerprint that is directly related to an ion’s precise conformation, particularly when measurements are performed at cryogenic temperatures. In our laboratory, we have constructed a hybrid instrument that combines all three techniques – MS, IMS, and cryogenic ion spectroscopy (CIS). This multidimensional approach allows one to leverage the advantages of each technique for augmenting the information available from each method separately. This talk will focus on two specific applications of cryogenic ion spectroscopy, combined in one case with MS and in the second case with IMS-MS. In the first, we use it to unravel the mystery of the serine octamer. Clusters of the amino acid serine show an extremely strong “magic number” at the octamer, which is also strongly homo-chiral, and this has caused some to speculate as to its role in chiral selection. However, the structure that gives rise to this selective behaviour has never been determined. We use cryogenic ion spectroscopy coupled to mass spectrometry, together with high-level quantum chemical calculations, to solve this mystery. The second application combines cryogenic ion spectroscopy with IMS-MS to determine the primary structure of oligosaccharides, or glycans. Glycosylation of proteins is one of the most common post-translational modifications, and the attached glycans play a fundamental role in all biological systems. Glycans attached to proteins or lipids are present at the surface of almost all cells and mediate cell-to-cell recognition and signaling, for example. They largely govern the interaction of cells with bacteria and viruses and are central to immune response and inflammation. Despite their importance, glycan structure is notoriously difficult to determine, because of the many different types of isomerization that can exist. We have shown that cryogenic vibrational spectroscopy is exquisitely sensitive to even the slightest change in structure and can easily distinguish all types of glycan isomerization. This talk will present our initial results applying this approach and explain how it could lead to high-throughput sequencing of glycans.

Location: 

Carol Lynch Lecture Hall, Chemistry Complex

Attached Document: 
inquires please contact Rosa M. Vargas rvargas@sas.upennn.edu

Physical Chemistry Seminar Dr. Jing Wang(Stony Brook University)

Thu, 2017-10-26 13:00 - 14:00
Speaker: 
Host: Nitzan
Location: 

Carol Lynch Lecture Hall, Chemistry Complex

Title: Landscape and Flux Theory of Nonequilibrium Physical and Biological Systems

 

Physical Chemistry Seminar Dr. Reshef Tenne (Weizmann Institute- Israel)

Thu, 2017-10-05 13:00 - 14:00
Speaker: 
Host: Nitzan
Location: 

Carol Lynch Lecture Hall , Chemistry Complex

Attached Document: 

Title: Inorganic nanotubes and fullerene-like nanoparticles from 2D compounds at the crossroad between materials science and nanotechnology and their applications

Inorganic Chemistry Seminar Dr. Stefan Minasian (Lawrence Berkeley Laboratory)

Tue, 2018-04-17 12:00 - 13:00
Speaker: 
Host: Tomson
Location: 

Carol Lynch Lecture Hall , Chemistry Complex

Inquires please contact Rosa M. Vargas rvargas@sas.upenn.edu

Department of Chemistry

231 S. 34 Street, Philadelphia, PA 19104-6323

215.898.8317 voice | 215.573.2112 fax | web@chem.upenn.edu

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