Biological Chemistry seminar: Ned Wingreen, Princeton University

Thu, 2019-04-18 15:00 - 16:00

Ned Wingreen

Princeton University

 

Biological Chemistry seminar, Susan Marqusee, University of California, Berkeley

Thu, 2019-04-11 15:00 - 16:00
Location: 

Carolyn Hoff Lynch Room

"Protein Folding On and Off the Ribosome"

Biological Chemistry seminar, Jake Jaffe, Broad Institute

Thu, 2019-03-28 15:00 - 16:00
Speaker: 

Jacob D. Jaffe

The Broad Institute

 

Lauren Rachel Zeitels Memorial Lecture

BIOLOGICAL CHEMISTRY SEMINAR

 

 

"Proteomic Connectivity Maps for Characterization and Targeting of Drugs" 

 

There has been an explosion of drug development in the kinase inhibitor and epigenetic modulator spaces.  The primary effects of both classes are fundamentally proteomic, altering the landscape of post-translational modifications in cells.  Mass spectrometry-based proteomic assays are uniquely suited to report on the molecular effects of these drugs. We have developed two scalable proteomic assays to this end: the P100 sentinel assay, which broadly reports on a wide range of signaling activities by monitoring a reduced-representation of the phosphoproteome, and the Global Chromatin Profiling assay, which monitors nearly all of the combinations and permutations of histone modifications commonly present in cells.  We generated a first-of-its-kind systematic library resource of proteomic drug signatures in cells. The majority of drugs generated reproducible signatures, but our analyses indicate the difficulty of identifying traditional “biomarkers” of activity that are paradigmatic for drug development. Eschewing biomarkers, we compared signatures using the "connectivity" concept, enabling data integration across cell types and assays, and co-integration of transcriptional signatures. Connectivity among cell types revealed cellular responses that transcended lineage, while connectivity agreement among assays revealed unexpected associations between drugs.  We further leveraged the resource against public data to recognize therapeutic hypotheses for treatment of multiple myeloma and acute lymphocytic leukemia. 

 

 

 

Thursday, March 28, 2019

3:00 PM

 

Carolyn Hoff Lynch Lecture Hall

 

Host:  Dr. David Christianson

Biological Chemistry seminar: Thomas Pologruto

Thu, 2018-11-15 15:00 - 16:00
Location: 
Carolyn Hoff Lynch Room

"Introduction to Econophysics"

Biological Chemistry seminar: Andres Finzi, Université de Montreal

Thu, 2018-10-04 16:00 - 17:00
Location: 

Carolyn Hoff Lynch Room

Note 4:00 start time.

"Identification of a new HIV-1 Env conformation vulnerable to antibody attack"

Host: Dr. Amos Smith

Biological Chemistry seminar: Jason Beiger, Amgen

Thu, 2019-04-04 15:00
Location: 

Carolyn Hoff Lynch Room

Host: Dr. Ponzy Lu

 

 

John C. Makris Memorial Lecture

 

Jason Beiger

Amgen

 

"Sulfonamides as Selective Nav1.7 Inhibitors for the Treatment of Pain"

Biological Chemistry seminar: Joseph Han, University of Pennsylvania

Thu, 2018-09-27 15:00 - 16:00
Location: 

Carolyn Hoff Lynch Room

"Dissecting the molecular basis of the Scaffold Protein JADE1 in HBO1 Histone Acetyltransferase (HAT) activity"

Biological Chemistry seminar: David Chenoweth, University of Pennsylvania

Thu, 2018-12-13 15:00 - 16:00
Location: 

Carolyn Hoff Lynch Room

"Rational redesign of the collagen triple helix"

2018 Joullie Lecture (Dale Boger, Scripps)

Wed, 2018-09-12 16:00
Speaker: 
Prof. Dale Boger, Scripps Research Institute
Location: 
Lynch Lecture Hall
"Redesign of Vancomycin for Resistant Bacteria"

Physical Chemistry Seminar, Dr. Matthias Waegele, Boston College

Thu, 2019-04-18 13:00 - 14:00
Speaker: 

Dr. Matthias Waegele

Location: 

Carol Lynch Lecture Hall

Chemistry Complex

"Elucidating the Molecular Origins of the Product Selectivity of Electrocatalytic Reactions"

Department of Chemistry

231 S. 34 Street, Philadelphia, PA 19104-6323

215.898.8317 voice | 215.573.2112 fax | web@chem.upenn.edu

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