Organic Chemistry Seminar Dr. Vladimir Gevorgyan ( University of Illinois)

November 13, 2017 - 12:00 PM - 01:00 PM
Speaker: 
Host: Kozlowski
Location: 
Carol Hoff Lynch Lecture Hall Chemistry Complex
Attached Document: 

-->DEVELOPMENT OF NOVEL C–H FUNCTIONALIZATION METHODOLOGIES  

 

We have developed a set of new transition metal-catalyzed C-H functionalization methodologies employing a silicon-tether motif.  These methods feature: (a) use of silyl group as a tether between a substrate and a reagent, thus transforming intermolecular reaction into an intramolecular reaction; (b) employment of a silicon-tethered directing group, which is traceless or easily convertable into valuable functionalities; (c) use of reactive silyl-tethered hydrosilane group; and (d) introduction of new N/Si-chelation concept that allows for a remote activation of aliphatic C-H bonds.

We have also uncovered new reactivity of hybrid Pd-radical species, generated at room temperature under visible light without exogenous photosensitizers, which lead to development of novel transformations, including new types of Heck reaction and proximal and remote C–H functionalization methods.

The scope of these transformations will be demonstrated and the mechanisms will be discussed. 

 

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