César de la Fuente

César de la Fuente is a Presidential Assistant Professor at the University of Pennsylvania, where he leads the Machine Biology Group. Previously, he pursued postdoctoral research at the Massachusetts Institute of Technology (MIT) and earned a PhD at the University of British Columbia (UBC). His research goal is to use the power of machines to accelerate discoveries in biology and medicine.

Biological Chemistry Seminar: Dr. Laura Sanchez

In nature, small molecules are often produced by macro- and microorganisms in order to facilitate communication and drive biological processes to the benefit (or detriment) of the community as a whole. Chemical gradients and chemical cues via the production of small molecules are ubiquitous across biological systems and my lab has previously applied imaging mass spectrometry (IMS) to study these cues and gradients in microbial systems. IMS can detect molecular signatures of interest in a sample as well as their spatial distributions across the entire sample.

Biological Chemistry Seminar: Dr. Kathy Liu

My laboratory is interested in understanding enzyme-mediated RNA processing in sex-specific gene regulation. It has been demonstrated recently that a diverse set of enzyme-mediated modifications are found internally within RNAs, which markedly influence the fate of RNAs in the cell. Many enzymes responsible for regulating protein and DNA modifications are targets of current therapies. RNA epitranscriptomics, the study of RNA modifications, is the new frontier in this arena.