An introduction to the theory and practice of structure determination by X-ray crystallography. Topics discussed include point group and space group symmetry, structure factor theory, data collection methods and a survey of solution methods. The course culminates with a series of real-world structure determinations worked through in-class using the XSeed program package.

This course focuses on current topics in Chemical Biology, particularly experiments in which 1) chemical synthesis enables one to probe or control biological systems, or 2) manipulation of biological systems facilitates novel chemical syntheses. The course is broadly divided into two sections, one dealing with the study of individual proteins and nucleic acids, and one dealing with complex cellular systems. As the goal of the course is to familiarize students with innovative recent experimental approaches and to stimulate them to conceive of their own new methodology, students will be responsible for delivering presentations on topics selected from the literature, designing experiments to address currently unsolved problems in Chemical Biology (in take-home examinations), and generating several novel research proposal ideas, one of which will be elaborated into a full proposal.

The focus of this course comprise the development of two synthetic strategies to access architecturally complex natural products of biological significance exploiting innovative chemistry. Lectures towards this end are given. As a project, each studnet is given a different complex natural product and expected at the end of the course to deveop two strategies, one based on asymmetric induction to provide the absolute stereochemical structure, the second where the absolute stereochemistry derives from commercially available starting materials.

Advanced laboratory work on the synthesis, structure, and properties of organic and inorganic compounds. Infrared, ultraviolet, and nuclear magnetic resonance spectroscopy. Lectures cover the theoretical basis and applications of modern spectroscopic methods.

A general laboratory course covering aspects of qualitative and quantitative analysis, determination of chemical and physical properties, and chemical synthesis.

(1) Advanced study and research in various branches of chemistry. (2) Seminar in current chemical research. (3) Individual tutorial in advanced selected topics.

Fundamental course in organic chemistry based upon the modern concepts of structure and mechanism of reactions. Laboratory included.

Fundamental course in organic chemistry based upon the modern concepts of structure and mechanism of reactions.

CHEM 5411 is a high level overview of classical physical organic chemistry. Undergraduate organic chemistry is a prerequisite. The course is divided into three parts. The first part will be an overview of organic bonding (basic molecular orbital theory, anomeric effect), structure (bond lengths, bond angles, conformational analysis), and properties (electronegativity, nucleophilicity, electrophilicity, acidity, basicity). The second part will be a brief overview of current computational methods including molecular mechanics, Hartree Fock, and density functional calculations. The focus will be on practical applications rather than the theory behind the calculations; students will be able to assess which calculations are most appropriate for a given task. The last part of the course will survey thermodynamic and kinetic measurements used in understanding organic chemical reactions. Topics include Hammett analyses, kinetic measurements and interpretation, the Hammond postulate, Arrhenius theory, Eyring theory, and kinetic isotope effects. Articles discussing these techniques in delineating the organic reaction mechanisms for problems of current interest will be analyzed. The focus will be on experiments that can be accomplished with readily available analytical tools (NMR, IR, UV, GC, HPLC) and how simple physical organic analyses can be used to optimize reaction yields and selectivities.

Basic concepts and principles of chemistry and their applications in chemistry and closely-related fields. The first term emphasizes the understanding of chemical reactions through atomic and molecular structure. This is a university level course, treating the material in sufficient depth so that students can solve chemical problems and can understand the principles involved in their solution. It includes an introduction to condensed matter. This course is suitable for majors or non-majors and is recommended to satisfy either major or pre-professional requirements for general chemistry. This course is presented for students with high school chemistry and calculus. Students with a lesser background than this should take CHEM 1011. Prerequisite: Students with credit for CHEM 1011 may not enroll in CHEM 1012. Credit is not awarded for both CHEM 1011 and CHEM 1012.