CHEM 1011 is an introductory college-level course in chemistry intended for students with less preparation in high school chemistry and mathematics. The course content parallels that of CHEM 1012, but with emphasis placed on developing problem-solving strategies and developing the underlying chemical principles. The course will take an 'atoms first' approach to introductory chemistry, where topical coverage includes an overview of quantum theory, atomic structure, the periodic table, chemical bonding, elementary chemical reactions, stoichiometry, ideal gases, and intermolecular interactions. Topics from mathematics and physics that are necessary to chemical problem-solving will be included as needed. Prerequisite: Students with credit for CHEM 1012 may not enroll in CHEM 1011. Credit will not be awarded for both CHEM 1011 and 1012.

CHEM 1011 is an introductory college-level course in chemistry intended for students with less preparation in high school chemistry and mathematics. The course content parallels that of CHEM 1012, but with emphasis placed on developing problem-solving strategies and developing the underlying chemical principles. The course will take an 'atoms first' approach to introductory chemistry, where topical coverage includes an overview of quantum theory, atomic structure, the periodic table, chemical bonding, elementary chemical reactions, stoichiometry, ideal gases, and intermolecular interactions. Topics from mathematics and physics that are necessary to chemical problem-solving will be included as needed. Prerequisite: Students with credit for CHEM 1012 may not enroll in CHEM 1011. Credit will not be awarded for both CHEM 1011 and 1012.

CHEM 1011 is an introductory college-level course in chemistry intended for students with less preparation in high school chemistry and mathematics. The course content parallels that of CHEM 1012, but with emphasis placed on developing problem-solving strategies and developing the underlying chemical principles. The course will take an 'atoms first' approach to introductory chemistry, where topical coverage includes an overview of quantum theory, atomic structure, the periodic table, chemical bonding, elementary chemical reactions, stoichiometry, ideal gases, and intermolecular interactions. Topics from mathematics and physics that are necessary to chemical problem-solving will be included as needed. Prerequisite: Students with credit for CHEM 1012 may not enroll in CHEM 1011. Credit will not be awarded for both CHEM 1011 and 1012.

Natural products, such as tetrodotoxin, kainic acid and morphine, have played a crucial role in the development of neuroscience. Using selected chemical syntheses as a framework, I will provide an introduction to neuroscience for chemists blended with an intense course in synthetic design ("Syntheseplanung"). The structure, function and synthesis of the following molecules will be analyzed: tetrodotoxin, saxitoxin, kainic acid, nicotine, epibatidine, coniine, tubocurarine, histrionicotoxin, ibotenic acid, strychnine, picrotine, chrysanthemic acid, ivermectin, muscarine, morphine, salvinorin A, THC, lysergic acid, forskolin, staurosporin, eglumegad, physostigmine, huperzin A, galanthamine, cocaine, reserpine, thapsigargin, ouabagenin, ryanodine, capsaicin, resiniferatoxin, retinal, carotene, menthol, santalol, camphor, and the prostaglandins. The structure and function of important ion channels, GPCRs, transporters and enzymes and their ligands will be discussed using PyMol files.
The goal of this course is to get as many synthetic chemists excited about neuroscience as possible (and a few neuroscientists stoked about synthesis). The importance of structural and pharmacological databases (PDB and IUPHAR, respectively) and the usefulness of the Reaxys database (and SciFinder) for synthetic planning will be demonstrated.
Requirements: A familiarity with synthetic organic chemistry and (named) chemical reactions, a mastery of the Nernst equation, and a willingness to learn more about one of the greatest, if not the greatest scientific challenges of our times: to figure out how the human brain work

Fundamental course in organic chemistry based upon the modern concepts of structure and mechanism of reactions. Laboratory included.

This course examines the structure and organization of the chemical literature in the field of biological chemistry and introduces techniques used to search this literature, focusing on the logic and thought processes necessary for effective information retrieval. The course takes an "under the hood" look at the organization and functionality of a variety of different databases and search systems, and, while learning information retrieval skills, students gradually become familiar with the structure of the chemical literature, the purposes of each genre, and the steps of the scientific publication process. Search skills are taught using a combination of lecture and laboratory activities, and students learn advanced text-based search techniques, protein and nucleotide sequence and structure similarity search strategies, basic substructure and reaction search strategies, and methods of retrieving property information and profiling substances by their properties. Students will also undertake a detailed examination protein and small molecule crystal structure databases. In addition to search skills, the students are exposed to strategies for choosing a publication venue; the use and limitations of citation information when evaluating authors, institutions, and journals; and the basic principles behind peer review. The semester closes with a brief introduction to personal data management and an in-depth discussion of the ethics surrounding scientific communication.
The course is taught at a level appropriate for graduate students and advanced undergraduates and requires permission of the instructor to register. Undergraduate students should have taken two semesters of organic chemistry prior to enrolling. Students should have an interest in biochemistry or molecular biology research.

This course examines the structure and organization of the chemical literature in the fields of physical and theoretical chemistry chemistry and introduces techniques used to search this literature, focusing on the logic and thought processes necessary for effective information retrieval. The course takes an "under the hood" look at the organization and functionality of a variety of different databases and search systems, and, while learning information retrieval skills, students gradually become familiar with the structure of the chemical literature, the purposes of each genre, and the steps of the scientific publication process. Because of the diversity of research foci in physical and theoretical chemistry, the course is survey in nature, devoting time to a wide variety of tools and search strategies and demonstrating Penn’s collections in chemistry, mathematics, physics, materials science, and engineering. In addition to teaching search skills, we briefly examine methods of choosing a publication venue and the use and limitations of citation information when evaluating authors, institutions, and journals. The semester closes with a brief introduction to personal data management and a discussion of the ethics surrounding scientific communication.
The course is taught at a level appropriate for graduate students and advanced undergraduates and requires permission of the instructor to register. Undergraduate students should have taken two semesters of organic chemistry prior to enrolling. Students should have an interest in physical or theoretical chemistry research.

Physical Organic I is an introduction to advanced physical organic chemistry. Mechanism drawing with arrows to denote the movement of an electron density will be a unifying theme. The course will overview organic bonding (basic molecular orbital theory, anomeric effect), structure (bond lengths, bond angles, delocalization and resonance, conformational analysis), and reactivity (electronegativity, nucleophilicity, electrophilicity, acidity, basicity, stereoelectronics).

This half-semester course continues to emphasize organic reactions, reaction mechanisms, and their strategic applications in complex molecule synthesis. Topics covered include oxidations, reductions, carbon-carbon bond formations, and strategic applications of protecting groups.

This course focuses on organic reactions, reaction mechanisms, and the strategic applications of these reactions in organic synthesis. Topics include symmetry, stereochemistry, stereoselectivity, olefinations, olefin metathesis, transition-metal catalyzed cross couplings, cycloadditions, electrocyclizations, sigmatropic rearrangements, and other pericycylic reactions. The material will be illustrated by applications in multistep chemical synthesis. Based on this course, students should be able to read the modern literature, develop independent research proposals in organic chemistry, and succeed in graduate school.