Special Biological Chemistry Seminar, Ralph Kleiner, The Rockefeller University

Mon, 2015-12-21 13:00 - 14:00
Location: 

Carolyn Hoff Lynch Room

For inquiries contact Camille Pride at campride@sas.upenn.edu 

 

Title:   Chemical Approaches to Illuminate Cellular Mechanisms Ensuring Genome Stability

 

Abstract:

The maintenance of genome stability is a major challenge faced by cells and errors in this process can lead to developmental defects and diseases such as cancer. In this seminar, I will describe the development and application of chemical tools to investigate fundamental molecular mechanisms ensuring genome stability. Using a chemical proteomics approach, we profiled, in native proteomes, direct binders of the phosphorylated histone variant, gH2AX, a central mediator of DNA double-strand break repair. These studies led to the identification of proteins that ‘read’ gH2AX, including the DNA repair protein, 53BP1, whose localization at chromosomal DNA breaks was shown to involve direct recognition of this phospho-‘mark’. I will also highlight progress towards profiling histone-mediated interactions in living cells involved in accurate chromosome segregation. This work shows how recognition of specific chemical epitopes within chromatin contributes to essential mechanisms that maintain genome stability, and demonstrates the utility of chemical approaches for the discovery and characterization of macromolecular interactions occurring in the cellular context.

Special Biological Chemistry Seminar, Siddhesh Kamat, The Scripps Research Institute

Thu, 2015-12-17 13:00 - 14:00
Location: 

Carolyn Hoff Lynch Room 

Inquiries please contact Camille Pride at campride@sas.upenn.edu 

 

Title: A lipid signaling pathway that controls immune cell extravasation in a human neurological disease

 

Abstract: 

Understanding hereditary human disorders has benefited from DNA sequencing technologies, which have, to date, facilitated determination of the genetic basis for over 4,000 inherited diseases in humans. Assigning biochemical and cellular functions to the proteins encoded by these mutated genes is critical to achieve a deeper mechanistic understanding of human genetic disorders and for identifying potential treatment strategies for these diseases. Several hereditary nervous system diseases are caused by deleterious mutations in poorly characterized enzymes from the serine hydrolase class. PHARC (polyneuropathy, hearing loss, ataxia, retinal pigmentation, cataract) is one such neurological disease, caused by deleterious null mutations in the Abhd12 gene, which encodes the serine hydrolase ABHD12. The major symptoms of PHARC include polymodal sensorimotor defects linked to peripheral neuropathy, hearing loss, early onset of cataract and blindness, cerebellar atrophy and demyelination of sensorimotor neurons. The Cravatt lab determined using Abhd12–/– mice and lipidomics that ABHD12 serves as a major lysophosphatidylserine (lyso-PS) lipase in the mammalian brain, degrading lyso-PS to produce glycerophosphoserine (GPS) and free fatty acid (FFA). Recently we have identified and functionally annotated ABHD16A as the principal phosphatidylserine (PS) lipase in the mammalian central nervous system and the immune system, where it regulates immunomodulatory lyso-PS production. Our studies thus designate ABHD16A as a key enzyme that functions upstream of ABHD12, and that these enzymes together form a dynamic pathway for regulating lyso-PS signaling in vivo. Furthermore we have found that lyso-PS lipids are intricately involved in immune cell trafficking, and are in particular critical for the extravasation of T-cells into tissues. I will present our lipidomics and immunological findings in mouse genetic models that support the broader role for the ABHD16A-ABHD12-lyso-PS signaling network in (neuro)-immunology.

 

 

Special Biological Chemistry Seminar, Yael David, Princeton University

Fri, 2015-12-04 13:00 - 14:00
Location: 

Carolyn Hoff Lynch Room

Inquires please contact Camille Pride at campride@sas.upenn.edu

 

Title:    Chemistry on Chromatin: Modifying Histones In Vivo Using Protein Trans-Splicing

Schelter Group Wins Postdoctoral Fellowship

Associate Professor Eric Schelter has been awarded a Postdoctoral Program in Environmental Chemistry from the Dreyfus Foundation. The award provides a principal investigator with a two year fellowship to appoint a Postdoctoral Fellow to perform fundamental research in the chemical sciences or engineering related to the environment. More information on the program can be found here.

Zahra Fakhraai Research Featured

Assistant Professor Zahra Fakhraai is part of an interdisciplinary team that received a five-year, $3.6 million grant from the National Science Foundation to develop materials for multifunctional coatings on emergency tents, enabling them to manage water, prevent the spread of bacteria and capture and store solar energy.

 

Organic Chemistry Seminar (Andy Peat, GlaxoSmithKline)

Mon, 2016-02-08 12:00 - 13:00
Location: 

Lynch Lecture Hall Chemistry Complex

Inquires please contact Camille Pride at campride@sas.upenn.edu

 

Inorganic Chemistry Seminar (Kirill Kovnir, University of California, Davis)

Tue, 2016-01-26 12:00 - 13:00
Location: 

Lynch Lecture Hall

Chemistry Complex

Inquires please contact Camille Pride at campride@sas.upenn.edu

 

Inorganic Chemistry Seminar (Vlad M. Iluc, University of Notre Dame)

Tue, 2016-04-19 12:00 - 13:00
Location: 
Lynch Lecture Hall Chemistry Complex

Inquires please contact Camille Pride at campride@sas.upenn.edu

Inorganic Chemistry Seminar (Marion Emmert, Worcester Polytechnic Institute)

Tue, 2016-03-22 12:00 - 13:00
Location: 

Lynch Lecture Hall Chemistry Complex

Inquires please contact Camille Pride at campride@sas.upenn.edu

 

 

Title:   Breaking Strong Bonds and Recovering Rare Earths: Adventures in Sustainable Chemistry

 

Joullié Group Green Chemistry Proposal Makes Semi-Finals

Prof. Madeleine Joullié's proposal for the Green and Sustainable Chemistry Challenge has made it to the semi-finals.

 

Of the 495 proposals submitted, the top 53 entries were selected based on the ratings of the reviewers. These 53 proposals have been sent to the scientific jury members and the jury will select the Top 5. The Top 5 contestants will be invited for the Green and Sustainable Chemistry Conference.

Department of Chemistry

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