ACS Section Award Lecture: Donna Huryn, UPenn

Thu, 2016-01-21 18:00 - 19:00
Speaker: 

Prof. Donna Huryn

Universirty of Pennsylvania

Location: 
Lynch Lecture Hall

Adventures in Academic and Industrial Medicinal Chemistry: Looking at Drug Discovery from Both Sides Now.

 

Reception at 5:00PM in Nobel Hall.

Special Biophysical Chemistry Seminar: Christy Landes, Rice

Wed, 2016-01-20 13:00 - 14:00
Speaker: 

Prof. Christy Landes

Rice University

Location: 
Lynch Lecture Hall
Attached Document: 

Single molecule dynamics at soft interfaces: from basic science to a $100,000,000,000 problem

 

Abstract

Andrew Rappe's Research Featured

A multidisciplinary team led by Andrew Rappe has discovered a way to control UV light production through a chemical reaction that functions like a light switch. According to Rappe, this is the first report of the introduction of molecules to the surface controlling the emission of light from a buried solid-surface interface. The research was highlighted as a featured paper by the US Department of Energy.

Ryan Kubanoff

Photo: 
First Name: 
Ryan
Last Name: 
Kubanoff
Official Title: 
Research Coordinator
Contact Information
Email: 
kubanoff@sas.upenn.edu

ACS Philadelphia Section Award Lecture

Thu, 2016-01-21 18:00 - 19:00
Speaker: 

Dr. Donna Huryn

University of Pennsylvania

Location: 
Lynch Lecture Hall

Madeleine Joullié to Receive John Scott Award

Madeleine Joullié will be one of the recipients of the prestigious John Scott Award this Friday. The award was founded in the early 19th century by John Scott, an Edinburgh chemist. The first awards were bestowed in 1834. The award is currently administered by the Board of Directors of City Trusts of the City of Philadelphia.

 

Special Seminar in Energy Research: F.N. Castellano (NC State)

Mon, 2015-11-23 13:00 - 14:00
Speaker: 

Prof. F.N. Castellano

Department of Chemistry

North Carolina State University

Location: 
Lynch Lecture Hall

Photochemical Upconversion: Molecules, Materials, and New Frontiers

 

Abstract

Special Biological Chemistry Seminar, Franziska Bleichert, John Hopkins University School of Medicine

Tue, 2016-01-12 13:00 - 14:00
Location: 

Carolyn Hoff Lynch Room

Title: Molecular mechanisms for initiating DNA replication in eukaryotes

Abstract:

Cellular organisms must replicate their DNA in a timely and accurate manner to preserve gene copy number, chromosome ploidy, and genome stability. In eukaryotes, DNA replication is initiated at specific sites throughout the genome, termed replication origins, which are bound by a multi-subunit protein assembly, the origin recognition complex (ORC). Aided by accessory factors, ORC facilitates loading of the replicative helicase core onto DNA to “license” origins for subsequent DNA replication.

In my seminar, I will describe how we used single-particle electron microscopy and X-ray crystallography to gain molecular insights into how the ORC subunits co-assemble, how ORC engages origin DNA, and how ORC interacts with partner proteins. I will discuss structure-guided models for how ORC operates during replicative helicase loading, as well as a novel mechanism for controlling metazoan ORC activity that may help regulate the onset of DNA replication in vivo. In addition, I will highlight how mutations in ORC subunits link ORC assembly defects to primordial dwarfism in humans.

 

Special Biological Chemistry Seminar, Vinayak Argarwal, The University of California San Diego

Mon, 2016-01-11 13:00 - 14:00
Location: 

Carolyn Hoff Lynch Room

For inquiries contact Camille Pride at campride@sas.upenn.edu

 

Title: Understanding natural product biosynthetic routes for polybrominated pollutants and toxins in the marine environment

 

Abstract:

The marine environment provides a plenitude of naturally produced organic pollutants and toxins. Of these, polybrominated marine natural products, such as endocrine disrupting polybrominated diphenyl ethers, dioxins, and pyrroles, biomagnify in the marine food web and are available to be passed onto humans via seafood. Despite their recognized toxic potential, routes for the production of these polybrominated molecules in the marine metabolome have not been elucidated. This in turn hinders the development of diagnostic tools to discover and query the biosynthetic potential of other natural sources that introduce these polybrominated pollutants into the environment.

The research presented in this seminar takes a fresh look at these molecules from a biochemists’ perspective, and uses an interdisciplinary (meta)genome mining direction to characterize the biosynthetic routes of polybrominated pollutants and toxins. Based on a 'predictive retrobiosynthetic' approach, biosynthetic hypotheses are advanced that are then rigorously tested using a combination of genetic and biochemical experiments. Complemented by mass spectrometry and other analytical techniques, data generated during the course of this study will be used to drive the discovery of under-appreciated additional natural sources that are contributing to the human and environmental exposure to these naturally produced polybrominated pollutants. Furthermore, the research design recognizes and seeks to exploit the numerous opportunities that will present themselves for the advancement of halogenation enzymology and novel marine biochemistry.

Special Biological Chemistry Seminar, Gregory Alushin, National Heart, Lung, and Blood Institute, NIH

Thu, 2016-01-07 13:00 - 14:00
Location: 

Carolyn Hoff Lynch Room

For inquiries contact Camille Pride at campride@sas.upenn.edu

 

Title: Cytoskeletal structural plasticity in force generation and mechanosensation

 

Abstract:

Cytoskeletal filaments play a central role in the generation and transmission forces essential to fundamental biological processes including cell division, differentiation, and morphogenesis, and their dysfunction in disease states such as cancer. Utilizing structural studies with cryo-electron microscopy and complimentary biophysical / cell biological approaches, we aim to uncover the detailed mechanisms of the macromolecular interactions which orchestrate these events. At the molecular level, they are driven by conformational changes in the component proteins of these filaments, tubulin and actin, as well as their binding partners. I will discuss my previous studies of the GTP hydrolysis-dependent conformational cycle underlying microtubule dynamic instability, which is critical for generating forces to segregate chromosomes during mitosis and is the target of several chemotherapeutic drugs. I will then focus on our ongoing efforts to visualize conformational changes in actin filaments and closely associated binding partners key for both generating forces (myosin motor proteins) and sensing forces (adhesion proteins and, provocatively, actin filaments themselves) to facilitate mechanotransduction. By dissecting the detailed molecular mechanisms of mechanosensation pathways, our long-term aim is to develop novel targets for therapeutic intervention in cancer metastasis and regenerative medicine.

Department of Chemistry

231 S. 34 Street, Philadelphia, PA 19104-6323

215.898.8317 voice | 215.573.2112 fax | web@chem.upenn.edu

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