Continuation of CHEM 1101: General Chemistry Laboratory I

CHEM 1021 will be the second course in a two-semester sequence in general chemistry, where an introductory foundation in the energetic and dynamic nature of chemical reactivity will be developed. The course will survey general principles of thermodynamics, phase transitions, equilibrium, acid/base chemistry, and chemical kinetics as applied to elementary chemical reactions. Using this foundation, structure and function of organic compounds and solid-state structure will be surveyed upon which the former fundamental principles will be deployed to predict reactivity/stability.

CHEM 1021 will be the second course in a two-semester sequence in general chemistry, where an introductory foundation in the energetic and dynamic nature of chemical reactivity will be developed. The course will survey general principles of thermodynamics, phase transitions, equilibrium, acid/base chemistry, and chemical kinetics as applied to elementary chemical reactions. Using this foundation, structure and function of organic compounds and solid-state structure will be surveyed upon which the former fundamental principles will be deployed to predict reactivity/stability.

This course focuses on concepts and strategies in medicinal chemistry, and how it is applied to modern drug discovery and development.
Med Chem II builds on the material in Med Chem I and focuses on specific drug targets such as enzyme, G-protein coupled receptors, channels, nucleic acids and protein-protein interactions. Additionally, therapeutics area specific medicinal chemistry and drug discovery applications will be covered including anti-cancer agents, anti-infectives (antibiotics and anti-virals), and therapeutics to treat psychiatric and neurodegenerative disorders. This course is geared to upper level undergraduate students in chemistry or biochemistry and graduate students. Completion of Session I is a prerequisite.

Continuation of CHEM 1101: General Chemistry Laboratory I

Continuation of CHEM 1101: General Chemistry Laboratory I

This course will provide an introduction of structure-property relationships in materials chemistry on length scales from atomic dimension up to the microscale and then draw on examples of Chemical design for "Energy and Environmental Sustainability." We will introduce the "12 Principles of Green Chemistry" and "12 Principles of Green Engineering" as a guide to modern materials chemistry design and follow a trajectory that proceeds with increasing length scales of ordering in the solid state. We will introduce techniques of x-ray, neutron, electron, and ion beam based scattering, real space imaging and spectroscopies and use these to explore non-crystalline materials (amorphous, glasses, and time permitting quasicrystals and aperiodic systems) and crystalline solids. Studies will proceed from atomic scales through nanoscale, mesoscale, and micro-scale discussing the emergence of band structure and delcocalized electronic and optical properties that emerge due to the finite scale of ordering and influence of the surface. Select examples will be drawn from advances in materials for in solar energy utilization with photochemistry and photoelectrochemistry and materials for photovoltaic and enabling advances electrochemical energy conversion and storage.

A continuation of X-ray I. This course will focus on the practical component of X-ray crystallography. Students will use crystallographic software (OLEX2, CrysAlisPRO, ShelX suite) to solve, refine, and finish small molecule crystal structures. These will include case studies and crystallographic problems such as the various types of disorder and twinning.

An introduction to the theory and practice of small molecule structure determination by X-ray crystallography. Topics discussed include point group and space group symmetry, structure factor theory, data collection methodology and a survey of solution methods. The course will include case studies of real-world structure determinations and interpreting X-ray structures.

This course focuses on current topics in Chemical Biology, particularly experiments in which 1) chemical synthesis enables one to probe or control biological systems, or 2) manipulation of biological systems facilitates novel chemical syntheses. The course is broadly divided into two sections, one dealing with the study of individual proteins and nucleic acids, and one dealing with complex cellular systems. As the goal of the course is to familiarize students with innovative recent experimental approaches and to stimulate them to conceive of their own new methodology, students will be responsible for delivering presentations on topics selected from the literature, designing experiments to address currently unsolved problems in Chemical Biology (in take-home examinations), and generating several novel research proposal ideas, one of which will be elaborated into a full proposal.