Physical Chemistry Seminar: Dr. Paul Cremer, Pennsylvania State University

September 20, 2018 - 01:00 PM - 02:00 PM
Speaker: 

Dr. Paul Cremer

" Probing the Interactions of Ions and Small Molecules with Phospholipid Membranes"

The interactions of ions and small molecules with lipid head groups depends intimately on the structure of the analytes and the chemical composition of the membrane. In this talk, it will be shown that these interactions can be facilely probed by fluorescence microscopy when using a pH sensitive probe. The ability of small organic species to insert into the membrane depends on the charge on the membrane, the charge on the small molecule, the presence of cholesterol, as well as the presence of other specific membrane lipids (e.g. phosphatidylethanolamine or phosphatidylglycerol). Further information on the insertion process can be obtained from sum frequency generation (SFG), Langmuir isotherm, and fluorescence recovery after photobleaching (FRAP) measurements. Intriguingly, it is revealed that the perturbation of the interfacial water structure can be correlated with the mechanisms of small molecule-membrane interactions under certain conditions. These types of interactions are significant because soluble drug molecules typically are meant to interact with specific protein receptors and membrane-drug interactions present an additional and often unintended influence.

 

 

Location: 

Carol Lynch Lecture Hall

Chemistry Complex

Attached Document: 

Host: Dr. Gai

 

inquiries rvargas@sas.upenn.edu

Department of Chemistry

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