Organic Chemistry Seminar Dr. Kevin Brown (Indiana University)

May 21, 2018 - 12:00 PM - 01:00 PM
Host: Kozlowski
Carol Lynch Lecture Hall Chemistry Complex
Attached Document: 

Metal Catalyzed Alkene Functionalization: An Approach Toward Stereospecific Cross-Coupling


Stereospecific cross-coupling of chiral alkyl metal intermediates is a recognized challenge in modern organic synthesis. Here an alternative strategy is presented in which a chiral alkyl metal is generated as a catalytic intermediate by boryl-metalation of an alkene.1-5 This method represents an attractive approach in chemical synthesis because two new bonds and two new stereocenters are generated in a single operation. In addition, due to the synthetic versatility of the carbon-boron bond, a variety of structures can be readily prepared, thus representing a general approach toward carbofunctionalization of alkenes. The scope, mechanistic details, and application to complex molecule synthesis will be discussed.


inquires Rosa M. Vargas

Department of Chemistry

231 S. 34 Street, Philadelphia, PA 19104-6323

215.898.8317 voice | 215.573.2112 fax |