Organic Chemistry Seminar (Justin Mohr, University of Illinois at Chicago)

May 08, 2017 - 12:00 PM - 01:00 PM
Location: 

Lynch Lecture Hall Chemistry Complex

Attached Document: 

 

 

Title:  Regio- and Stereocontrol with Anions and Radicals

 

 

Abstract:


Dienolates and their synthetic equivalents provide a versatile platform for regioselective functionalization protocols owing to their ambident reactivity.  Exploration of radical additions to these synthons is examined as a potential solution to the problem of γ-functionalization of cyclic ketones.  In addition, anioinic dienolates are studied as unusual regiodivergent branch points for the synthesis of halogenated arenes from common, readily available precursors.  Aspects of regio- and stereoselectivity are important components that provide mechanistic insights into these transformations.  In separate studies, selective scission of carbon–carbon bonds is investigated using ring strain as a directing element and activating effect.  Applications of these strategies in target-directed synthesis efforts are underway.

Department of Chemistry

231 S. 34 Street, Philadelphia, PA 19104-6323

215.898.8317 voice | 215.573.2112 fax | web@chem.upenn.edu