Chemical Physics and Physical Chemistry

Special Physical Chemistry Seminar (Leif Hammarstrom, Uppsala)

Thu, 2014-10-02 13:00 - 14:00
Speaker: 
Prof. Leif Hammarström Uppsala University
Location: 
Carol Lynch Lecture Hall Chemistry Complex
Attached Document: 

 

Molecular Mechanisms of Artificial Photosynthesis

 

Physical Chemistry Seminar (David Moore, Lehigh U )

Thu, 2014-08-28 13:00 - 14:00
Speaker: 
Prof. David Moore, Lehigh University
Location: 
Carol Lynch Lecture Hall Chemistry Complex
Attached Document: 

Inquiries Please contact Rosa Vargas rvargas@sas.upenn.edu

Emily Weiss, Northwestern (Special Physical Seminar)

Thu, 2014-06-26 13:00 - 14:00
Speaker: 

Prof. Emily A. Weiss

Northwestern University

 

Title: Electron Ratchets

Location: 

Lynch Lecture Hall

Attached Document: 

2014 NOBCChE Lecture

Thu, 2014-05-01 16:00 - 17:00
Speaker: 

Prof. John A.W. Harkless

Howard University

Location: 

Lynch Lecture Hall

Attached Document: 

The Research Life of a Minority Chemist: How a Difference in Perspective Aids Chemical Intuition

 

Jessica M. Anna

Photo: 
First Name: 
Jessica M.
Last Name: 
Anna
Official Title: 
Assistant Professor of Chemistry

Physical Chemistry, Laser Spectroscopy, Ultrafast Dynamics, Chemical Reaction Dynamics, and Energy Science

Additional Titles: 
Elliman Faculty Fellow
Contact Information
Office Location: 
251 Chem
Email: 
jmanna@sas.upenn.edu
Phone: 
215-746-2354
Admin Support: 
Education: 

B.S. University of Pittsburgh (2006)

 

Ph.D. University of Michigan (2011)

 

Postdoctoral Research Fellow, University of Michigan (2011)

 

Postdoctoral Research Fellow, University of Toronto (2011-2014)

Research Interests: 

Solar energy conversion, in both natural and artificial systems, involves the absorption of a photon that can then lead to a series of energy and electron transfer events. Research in the Anna group focuses on understanding these photoinitiated processes. More specifically we are interested in exploring (1) the interplay of vibrational motion with both electronic energy transfer and electron transfer reactions, and (2) the role the environment plays in these processes. To begin to answer these questions we employ both well-established and novel multidimensional spectroscopic techniques to explore photoinitiated processes in a range of systems, spanning interests in biology, chemistry, and physics.

Selected Publications: 

J. M. Anna, M. R. Ross, K. J. Kubarych, “Dissecting Enthalpic and Entropic Barriers to Ultrafast Equilibrium Isomerization of a Flexible Molecule Using 2DIR Chemical Exchange Spectroscopy”, J. Phys. Chem. A 113 (2009) 6544-6547.

 

J. M. Anna and K. J. Kubarych, “Watching Solvent Friction Impede Ultrafast Barrier Crossings: A Direct Test of Kramers Theory”, J. Chem. Phys. 133 (2010) 174596.

 

J. M. Anna, M. J. Nee, C. R. Baiz, R. McCanne, K. J. Kubarych, “Measuring Absorptive Two-Dimensional Infrared Spectra Using Chirped-Pulse Upconversion Detection”, J. Opt. Soc. Am. B. 27 (2010) 382-393.

 

J. M. Anna, E. E. Ostroumov, K. Maghlaoui, J. Barber, and G. D. Scholes “Two-Dimensional Electronic Spectroscopy Reveals Ultrafast Downhill Energy Transfer in Photosystem I Trimers of the Cyanobacterium Thermosynechococcus elongatus”, J. Phys. Chem. Lett. (2012), 3, 3677-3684.

 

J. M. Anna, Y. Song, R. Dinshaw and G. D. Scholes “Two-dimensional electronic spectroscopy for mapping photophysics”, Pure. Appl. Chem. (2013), 85, 1307-1319.

 

J. M. Anna, G. D. Scholes, and R. van Grondelle, “A Little Coherence in Photosynthetic Light Harvesting”, BioScience (2014), 64, 14-25

Elizabeth Rhoades

Photo: 
First Name: 
Elizabeth
Last Name: 
Rhoades
Official Title: 
Associate Professor of Chemistry
Contact Information
Office Location: 
258 Chemistry Building
Email: 
elizabeth.rhoades@sas.upenn.edu
Phone: 
215-573-6477
Fax: 
215-573-2112
Admin Support: 
Education: 
  • postdoctoral associate with Professor Watt Webb at Cornell University (2003-2006)
  • postdoctoral associate with Professor Gilad Haran at the Weizmann Institute of Science (2001-2003)
  • PhD in Biophysics from the University of Michigan, Ann Arbor (2001)
  • B.S. in Physics from Duke University (1994)
Research Interests: 

Research in the Rhoades lab aims to elucidate the principles that link protein conformational change with structure-function relationships, focusing on understanding structural plasticity in intrinsically disordered proteins (IDPs). IDPs do not form stable structures under physiological conditions; for many, function is dependent upon disorder. This is in striking contrast to the structure-function paradigm that dominates our understanding of globular proteins. Given the large fraction of the eukaryotic proteome predicted to be disordered, the scope of the problem and the need for new insights are enormous.

 

Much of our effort is directed towards IDPs whose aggregation is central to the pathology of several degenerative diseases: α-synuclein (Parkinson’s disease), tau (Alzheimer’s disease), and IAPP (Type II Diabetes). These three proteins have diverse native functions and binding partners, but share intriguing commonalities of toxic mechanism and the importance of templated selfassembly. Studying systems in parallel allows us to generate protein and disease-specific insights as well as determine principles relevant to general functional and dysfunctional mechanisms of IDPs.

 

Our primary approaches center on single molecule optical techniques. These approaches enable quantitative and structural assessments of our systems in isolation and in the context of biologically relevant interactions. Single molecule approaches are unique in their ability to characterize systems which exist and function as a dynamic ensemble of states.

Selected Publications: 

1.      X.-H. Li, J. A. Culver, and E. Rhoades (2015) “Tau binds to multiple tubulin dimers with helical structure” Journal of the American Chemical Society, 137: 9218-921


2.     A. Nath, D. E. Schlamadinger, E. Rhoades, and A.D. Miranker (2015) “Structure-based small molecule modulation of a pre-amyloid state: pharmacological enhancement of IAPP membrane-binding and toxicity” Biochemistry, 349: 54-58

3.     D. Jülich, G. Cobb,  A.M. Melo, P. McMillen, A. Lawton,  S.G.J. Mochrie, E. Rhoades, and S.A. Holley (2015) “Cross-scale Integrin regulation organizes ECM and tissue topology” Developmental Cell, 34: 33-44

4.     J. LaRochelle, G. Cobb, A. Steinauer, E. Rhoades, and A. Schepartz (2015) “Fluorescence correlation spectroscopy revealsy highly efficient endosomal escape by certain penta-arg proteins and stapled peptides” Journal of the American Chemical Society. 127: 2536-2541 January 2015

5.     S.Kumar, D.E. Schlamadinger, M.A. Brown, J.M. Dunn, B. Mercado, J.A. Hebda, I Saraogi, E. Rhoades, A.D. Hamilton, and A.D. Miranker (2014) “IAPP and the shared molecular origins of leakage and toxicity” Chemistry and Biology, 19: 369-378

6.     A.R. Braun, M.M. Lacy, V.C. Ducas, E. Rhoades, and J.N. Sachs (2014) “α-Synuclein-induced membrane remodeling is driven by binding affinity, partition depth, and interleaflet order asymmetry” Journal of the American Chemical Society, 136: 9962-9972

7.  S. Elbaum-Garfinkle, G. Cobb, J. T. Compton, X. Li and E. Rhoades (2014)“Tau mutants bind tubulin heterodimers with enhanced affinity” Proceedings of the National Academy of Sciences U.S.A., 111: 6311-6316

8.  D. C. DeWitt and E. Rhoades (2013) “α-Synuclein Inhibits SNARE-mediated Vesicle Fusion Through Direct Interactions with Lipid Bilayer” Biochemistry, 52: 2385-2387

9.  B. R. Capraro, Z. Shi, J.M. Dunn, T. Wu, E. Rhoades, and T. Baumgart (2013) “Kinetics of endophilin N-BAR domain dimerization and membrane interactions” Journal of Biological Chemistry, 288: 12533-12543

10.  S. Elbaum-Garfinkle and E. Rhoades (2012) “Long-Range Interactions Modulate Aggregation of Tau by Altering the Conformational Ensemble” Journal of the American Chemical Society, 134: 16607-16613

11.     A. Nath, M. Sammalkorpi, D. DeWitt, A.J. Trexler, S. Elbaum-Garfinkle, C.S. O’Hern and  E. Rhoades (2012) “The Conformational Ensembles of  α-Synuclein and Tau:  Combining Single-Molecule FRET and Simulations”  Biophysical Journal, 103: 1940-1949

12.     V. Ducas and E. Rhoades (2012) “Quantifying β-Synuclein and g-Synuclein Membrane Interactions”  Journal of Molecular Biology, 423:528-539

13.     A.J. Trexler and E. Rhoades  (2012) “N-terminal acetylation is critical for forming α-helical oligomer of α-Synuclein” Protein Science, 21:601-605  

14.     A.R. Braun, E. Sevcsik, P. Chin, E. Rhoades, S. Tristram-Nagle, and J.N. Sachs (2012) “α-Synuclein Induces Both Positive Mean Curvature and Negative Gaussian Curvature in Membranes” Journal of the American Chemical Society,  134: 2613-2620  

15.     A. Nath, A. D. Miranker, and E. Rhoades (2011) “A Membrane-bound Dimer of Islet Amyloid  Polypeptide Studied by Single-Particle FRET”  Angewandte Chemie, 50: 10859-10862   
   
16.     N.B. Last, E. Rhoades, and A.D. Miranker (2011) “Islet Amyloid Polypeptide Demonstrates A Persistent Capacity to Disrupt Membrane Integrity” Proceedings of the National Academy of Sciences, U.S.A., 108: 9460-9465   

17.     E. Sevcsik, A.J. Trexler, J.M. Dunn, and E. Rhoades (2011) “Allostery in a disordered protein: Oxidative modifications to α-Synuclein act distally to regulate membrane binding” Journal of the American Chemical Society, 133: 7152-7158  

18.  A.J. Trexler and E. Rhoades (2010) “Single molecule characterization of α-Synuclein in aggregation-prone states” Biophysical Journal, 99: 3048-3055    

19.  E. R. Middleton and E. Rhoades (2010) “Effects of vesicle curvature and composition on α-Synuclein binding to lipid vesicles” Biophysical Journal, 99: 2279-2288  

20.  A . J. Trexler and E. Rhoades (2009) “α-Synuclein binds large unilamellar vesicles as an extended helix”Biochemistry, 48: 2304-2306  

Junrong Zheng, Rice University , Physical Chemistry Seminar

Thu, 2014-04-24 13:00 - 14:00
Speaker: 

Junrong Zheng

Location: 

Lynch Lecture Hall

Chemistry Department

Inquiries Please contact Rosa Vargas rvargas@sas.upenn.edu

Tom Markland, Stanford University , Physical Chem Seminar

Thu, 2014-03-27 13:00 - 14:00
Speaker: 

Tom Markland

Location: 

Lynch Lecture Hall, Chem Dept

Inquiries Please contact Rosa Vargas rvargas@sas.upenn.edu

Special Energy Seminar: L. Robert Baker, Berkeley

Tue, 2013-11-26 22:00
Speaker: 

Dr. L. Robert Baker   
University of California, Berkeley

Location: 

Carolyn Hoff Lynch Lecture Hall
Chemistry Complex
231 South 34th Street

Attached Document: 

Charge Transfer and Chemistry at Catalytic Interfaces

Abstract

Rodney Priestley, Princeton U.; Special Physical Chem. Seminar

Tue, 2013-12-03 16:00 - 17:30
Location: 

Lynch Lecture Hall, Chem. Dept.

Department of Chemistry

231 S. 34 Street, Philadelphia, PA 19104-6323

215.898.8317 voice | 215.573.2112 fax | web@chem.upenn.edu

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