Biological

Biological Chemistry seminar: David Chenoweth, University of Pennsylvania

Thu, 2018-12-13 15:00 - 16:00
Location: 

Carolyn Hoff Lynch Room

"Rational redesign of the collagen triple helix"

Biological Chemistry seminar: Alan Saghetalian, Salk Institute

Thu, 2019-03-14 15:00
Location: 
Carolyn Hoff Lynch Room

Topic:  New small biological molecules

Host:  Dr. Megan Matthews

Biological Chemistry seminar: Binghe Wang, Georgia State University

Thu, 2019-02-21 15:00
Location: 
Carolyn Hoff Lynch Room

Topic:  Drug design

Host:  Dr. Ivan Dmochowski

Biological Chemistry seminar: John Schneekloth, NIH

Thu, 2019-02-07 15:00
Location: 

Carolyn Hoff Lynch Room

Topic:  Small molecule probes of DNA, RNA, proteins

Host:  Dr. David Chenoweth

Biological Chemistry seminar: Amanda E. Hargrove, Duke University

Thu, 2019-01-24 15:00
Location: 

Carolyn Hoff Lynch Room

Topic:  lncRNA

Host:  Dr. David Chenoweth

Biological Chemistry seminar: Jake Hooker, Harvard University

Thu, 2019-01-17 15:00
Location: 
Carolyn Hoff Lynch Room Host: Dr. David Christianson

Topic:  Molecules for human imaging

Host:  Dr. David Christianson

Biological Chemistry seminar: Karim-Jean Armache, New York University

Thu, 2018-12-06 15:00
Speaker: 

Karim-Jean Armache

New York University School of Medicine

 

"Mechanistic studies of gene silencing complexes"

 

Gene silencing is conserved from yeast to humans, playing a crucial function in establishment, maintenance and propagation of distinct patterns of gene expression. This process plays an essential role in development and its dysregulation can cause diseases including cancer. In all eukaryotes, regulation of gene activity is directed by packaging of DNA into chromatin. The fundamental repeating unit of chromatin is the nucleosome that comprises ~146 base pairs of DNA wrapped around an octamer of histone proteins. The nucleosome is the platform upon which proteins and protein complexes assemble to regulate chromosomal transactions such as gene transcription. These complexes act in part by modifying and/or binding to specific histone modifications. We use biochemical, biophysical and structural approaches to understand the detailed mechanisms of gene silencing complexes, their interplay with posttranslational modifications of histones and their effect on higher-order chromatin structure.

Location: 

Carolyn Hoff Lynch Room

Biological Chemistry seminar: Abhinav Nath, University of Washington

Thu, 2018-11-01 15:00
Location: 

Carolyn Hoff Lynch Room

Topic: Protein molecular dynamics and health

Host: Dr. Elizabeth Rhoades

Biological Chemistry seminar: Kabirul Islam, University of Pittsburgh

Thu, 2018-10-18 15:00
Location: 

Carolyn Hoff Lynch Room

"Protein and small molecule engineering towards an orthogonal chromatin landscape"

Host: Dr. E. James Petersson

Biological Chemistry seminar: Sua Myong, Johns Hopkins University

Thu, 2018-10-11 15:00
Location: 
Carolyn Hoff Lynch Room

"Defective RNA interaction leads to aberrant phase separation of ALS-linked mutant FUS"

Department of Chemistry

231 S. 34 Street, Philadelphia, PA 19104-6323

215.898.8317 voice | 215.573.2112 fax | web@chem.upenn.edu

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