General

Inorganic Chemistry Seminar Dr. Dave Harris ( Northwestern University)

Tue, 2018-04-03 12:00 - 13:00
Speaker: 
Host: Tomson
Location: 
Carol Lynch Lecture Hall, Chemistry Complex

Inorganic Chemistry Seminar Dr. Mark Antonio (Argonne National Laboratory)

Tue, 2018-02-06 12:00 - 13:00
Speaker: 
Host:Tomson
Location: 
Carol Lynch Lecture Hall, Chemistry Complex

Physical Chemistry Seminar, Dr. Lutz Maibaum (University of Washington, Seattle)

Thu, 2017-09-14 13:00 - 14:00
Speaker: 
Host:Subotnik
Location: 
Carol Lynch Lecture Hall, Chemistry Complex

Title Spatial organization of the plasma membrane and peripheral membrane proteins

Physical Chemistry Seminar Dr. Thomas Rizzo (École Polytechnique Fédérale de Lausanne)

Thu, 2017-10-12 13:00 - 14:00
Speaker: 

 

Host Lester

Title Cryogenic spectroscopy of biomolecular ions: From homo-chiral selection to carbohydrate analysis

 

Abstract While mass spectrometry (MS) has been a workhorse tool for the detection and identification of biological molecules, it is limited in its ability to determine 3-dimensional structure. When MS is combined with ion mobility spectrometry (IMS), which determines the orientationally averaged cross section of ions as they are dragged through a static gas, one gains valuable information on the molecular shape, albeit not the precise 3-D structure. On the other hand, adding a vibrational spectroscopic dimension to MS provides a fingerprint that is directly related to an ion’s precise conformation, particularly when measurements are performed at cryogenic temperatures. In our laboratory, we have constructed a hybrid instrument that combines all three techniques – MS, IMS, and cryogenic ion spectroscopy (CIS). This multidimensional approach allows one to leverage the advantages of each technique for augmenting the information available from each method separately. This talk will focus on two specific applications of cryogenic ion spectroscopy, combined in one case with MS and in the second case with IMS-MS. In the first, we use it to unravel the mystery of the serine octamer. Clusters of the amino acid serine show an extremely strong “magic number” at the octamer, which is also strongly homo-chiral, and this has caused some to speculate as to its role in chiral selection. However, the structure that gives rise to this selective behaviour has never been determined. We use cryogenic ion spectroscopy coupled to mass spectrometry, together with high-level quantum chemical calculations, to solve this mystery. The second application combines cryogenic ion spectroscopy with IMS-MS to determine the primary structure of oligosaccharides, or glycans. Glycosylation of proteins is one of the most common post-translational modifications, and the attached glycans play a fundamental role in all biological systems. Glycans attached to proteins or lipids are present at the surface of almost all cells and mediate cell-to-cell recognition and signaling, for example. They largely govern the interaction of cells with bacteria and viruses and are central to immune response and inflammation. Despite their importance, glycan structure is notoriously difficult to determine, because of the many different types of isomerization that can exist. We have shown that cryogenic vibrational spectroscopy is exquisitely sensitive to even the slightest change in structure and can easily distinguish all types of glycan isomerization. This talk will present our initial results applying this approach and explain how it could lead to high-throughput sequencing of glycans.

Location: 

Carol Lynch Lecture Hall, Chemistry Complex

Attached Document: 
inquires please contact Rosa M. Vargas rvargas@sas.upennn.edu

Physical Chemistry Seminar Dr. Jing Wang(Stony Brook University)

Thu, 2017-10-26 13:00 - 14:00
Speaker: 
Host: Nitzan
Location: 

Carol Lynch Lecture Hall, Chemistry Complex

Title: Landscape and Flux Theory of Nonequilibrium Physical and Biological Systems

 

Physical Chemistry Seminar Dr. Reshef Tenne (Weizmann Institute- Israel)

Thu, 2017-10-05 13:00 - 14:00
Speaker: 
Host: Nitzan
Location: 

Carol Lynch Lecture Hall , Chemistry Complex

Attached Document: 

Title: Inorganic nanotubes and fullerene-like nanoparticles from 2D compounds at the crossroad between materials science and nanotechnology and their applications

Inorganic Chemistry Seminar Dr. Stefan Minasian (Lawrence Berkeley Laboratory)

Tue, 2018-04-17 12:00 - 13:00
Speaker: 
Host: Tomson
Location: 

Carol Lynch Lecture Hall , Chemistry Complex

Inquires please contact Rosa M. Vargas rvargas@sas.upenn.edu

Jennifer Matsui Honored by BMS

Jennifer Matsui, a fourth-year student in Prof. Gary Molander's research group has been selected to receive a Bristol Myers Squibb Graduate Research Fellowship. Jennifer currently studies an area around the development of a mild, photoredox-mediated C-H alkylation procedure of heteroarenes using a wide variety of primary, secondary, and tertiary alkyltrifluoroborates.

Megan Matthews Joins Chemistry Department

Megan Matthews has officially joined the Department as an Assistant Professor of Chemistry. Megan, a bioinorganic chemist and chemical biologist by training, joins Penn after a stint as a Merck postdoctoral fellow of the Helen Hay Whitney Foundation in Prof. Ben Cravatt's group at The Scripps Research Institute in La Jolla, CA. Megan received her undergraduate degree in Chemistry from Miami University, and she performed her doctoral research with Profs. Marty Bollinger and Carsten Krebs at Penn State University.

 

Inorganic Chemsitry Seminar , Dr. Brandi Cossairt ( Univeristy of Washington)

Tue, 2018-03-13 12:00 - 13:00
Speaker: 
Host:Tomson
Location: 

Carol Lynch Lecture Hall, Chemistry Complex

Attached Document: 

The Chemistry of Nanoscale Phosphides: Building Complex Inorganic “Molecules” with Atom-Level Precision

 

Department of Chemistry

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