General

Special Biological Chemistry Seminar (Stavroula Hatzios, Harvard Medical School)

Fri, 2016-02-19 13:00 - 14:00
Location: 

Lynch Lecture Hall Chemistry Complex

Inquires please contact Camille Pride at campride@sas.upenn.edu

 

Organic Chemistry Seminar (Hidehiko Nakagawa, Nagoya City University)

Tue, 2016-01-26 14:00 - 15:00
Location: 

Lynch Lecture Hall Chemistry Complex

Inquires please contact Camille Pride at campride@sas.upenn.edu

 

BMS Lecture (Frank Glorius, Münster)

Mon, 2016-02-01 14:00 - 16:30
Speaker: 

Nicholas A. Meanwell

Bristol-Myers Squibb

The Discovery and Development of Direct Acting Inhibitors of Hepatitis C Virus 

 

Frank Glorius

Westfälische Wilhelms-Universität Münster

On Discovery in Catalysis

Location: 
Lynch Lecture Hall
Attached Document: 

ACS Section Award Lecture: Donna Huryn, UPenn

Thu, 2016-01-21 18:00 - 19:00
Speaker: 

Prof. Donna Huryn

Universirty of Pennsylvania

Location: 
Lynch Lecture Hall

Adventures in Academic and Industrial Medicinal Chemistry: Looking at Drug Discovery from Both Sides Now.

 

Reception at 5:00PM in Nobel Hall.

Special Biophysical Chemistry Seminar: Christy Landes, Rice

Wed, 2016-01-20 13:00 - 14:00
Speaker: 

Prof. Christy Landes

Rice University

Location: 
Lynch Lecture Hall
Attached Document: 

Single molecule dynamics at soft interfaces: from basic science to a $100,000,000,000 problem

 

Abstract

Andrew Rappe's Research Featured

A multidisciplinary team led by Andrew Rappe has discovered a way to control UV light production through a chemical reaction that functions like a light switch. According to Rappe, this is the first report of the introduction of molecules to the surface controlling the emission of light from a buried solid-surface interface. The research was highlighted as a featured paper by the US Department of Energy.

ACS Philadelphia Section Award Lecture

Thu, 2016-01-21 18:00 - 19:00
Speaker: 

Dr. Donna Huryn

University of Pennsylvania

Location: 
Lynch Lecture Hall

Madeleine Joullié to Receive John Scott Award

Madeleine Joullié will be one of the recipients of the prestigious John Scott Award this Friday. The award was founded in the early 19th century by John Scott, an Edinburgh chemist. The first awards were bestowed in 1834. The award is currently administered by the Board of Directors of City Trusts of the City of Philadelphia.

 

Special Seminar in Energy Research: F.N. Castellano (NC State)

Mon, 2015-11-23 13:00 - 14:00
Speaker: 

Prof. F.N. Castellano

Department of Chemistry

North Carolina State University

Location: 
Lynch Lecture Hall

Photochemical Upconversion: Molecules, Materials, and New Frontiers

 

Abstract

Special Biological Chemistry Seminar, Franziska Bleichert, John Hopkins University School of Medicine

Tue, 2016-01-12 13:00 - 14:00
Location: 

Carolyn Hoff Lynch Room

Title: Molecular mechanisms for initiating DNA replication in eukaryotes

Abstract:

Cellular organisms must replicate their DNA in a timely and accurate manner to preserve gene copy number, chromosome ploidy, and genome stability. In eukaryotes, DNA replication is initiated at specific sites throughout the genome, termed replication origins, which are bound by a multi-subunit protein assembly, the origin recognition complex (ORC). Aided by accessory factors, ORC facilitates loading of the replicative helicase core onto DNA to “license” origins for subsequent DNA replication.

In my seminar, I will describe how we used single-particle electron microscopy and X-ray crystallography to gain molecular insights into how the ORC subunits co-assemble, how ORC engages origin DNA, and how ORC interacts with partner proteins. I will discuss structure-guided models for how ORC operates during replicative helicase loading, as well as a novel mechanism for controlling metazoan ORC activity that may help regulate the onset of DNA replication in vivo. In addition, I will highlight how mutations in ORC subunits link ORC assembly defects to primordial dwarfism in humans.

 

Department of Chemistry

231 S. 34 Street, Philadelphia, PA 19104-6323

215.898.8317 voice | 215.573.2112 fax | web@chem.upenn.edu

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