General

Organic Chemistry Seminar: Dr. Munetaka Alita, TITECH

Tue, 2019-06-11 12:00 - 13:00
Speaker: 
Host Dr. Molander
Location: 
Carol Lynch Lecture Hall Chemistry Complex

“Fluoroalkylative olefin difunctionalization by highly reducing organic photoredox catalysts”

 

 

Munetaka Akita Laboratory for chemistry and life science, Tokyo Institute of Technology

 

 

Physical Chemistry Seminar: Dr. Joel Yuen-Zhou, University of California, San Diego

Thu, 2019-05-16 13:00 - 14:00
Speaker: 
Host: Subotnik/ Nitzan
Location: 
Chemistry Complex Lecture Room 102

Polariton chemistry: molecules in optical cavities

 

 

 

MacDiarmid Medal Lecture (Robert Bergman, Berkeley)

Wed, 2019-04-17 16:00
Speaker: 

Prof. Robert G. Bergman

University of California, Berkeley

Location: 
Lynch Lecture Hall
Attached Document: 

Graduate Students Honored by NSF

Vincent Esposito, a second-year graduate student in the Lester/Francisco groups, has been selected to receive a National Science Foundation Graduate Research Fellowship. Walter Johnsen of the Mallouk/Goldberg groups, Lucille Wells of the Kozlowski group, and Ethan Zars of the Mindiola Group received Honorable Mention.

 

Special Seminar in Chemistry & Engineering: Colin Bain, Durham University

Fri, 2019-03-22 13:00
Speaker: 
Colin D. Bain, Durham University
Location: 
Lynch Lecture Hall
Drops Behaving Badly

Chemistry Graduate Student Honored by ACS

Lauren Grant, a fourth year graduate student in the Mindiola group, has been selected to receive a 2019 ACS Division of Inorganic Chemistry Young Investigator Award. Recipients of this award are invited to participate in the DIC Young Investigator Symposium to be held at the Fall American Chemical Society meeting in San Diego. Recipients also receive an honorarium and a plaque.

Gilbert Stork Lecture (Andreas Pfaltz, Basel)

Mon, 2019-03-25 18:00
Speaker: 

Prof. Andreas Pfaltz

University of Basel

Location: 
Lynch Lecture Hall
Attached Document: 

Design and Screening of Chiral Catalysts for Asymmetric Sythnthesis

Biological Chemistry seminar: Gabriel Rosenblum, Weizmann Institute of Science

Thu, 2019-03-07 15:00 - 16:00
Speaker: 

Gabriel Rosenblum

Department of Structural Biology

Weizmann Institute of Science

 

"Observation of Allosteric Signaling Through DNA with Single-Molecule FRET and Cryo-EM"


Gene networks often obey complex dynamics such as pulsing and oscillations that require a nearly binary “on” and ”off” switch in gene activity. At a molecular level, a high cooperativity in the interaction between transcription factors (TFs) and DNA is key for this switch. However, how this cooperativity is achieved is unknown for many systems. We used a combination of cryo-electron microscopy (cryo-EM) and single-molecule fluorescence spectroscopy to unravel the emergence of cooperativity in the interaction between ComK, a bacterial transcription factor from Bacillus subtilis, and its promoter sequence. The promoter contains two binding sites (AT-boxes) that are separated by 18 base pairs (6 nm). Single-molecule FRET experiments show a low cooperativity for the binding to individual AT-boxes whereas the combination of two distant binding sites in the natural promoter boosts cooperativity. Importantly, the boost does not result from interactions between ComK-molecules at the two sites, as revealed by a cryo-EM structure of the ComK-DNA complex. Instead, the results unravel a new allosteric mechanism. Cooperativity between the ComK-binding sites results from an axially transmitted signal through the DNA-structure. Hence, ComK-binding to one site increases the affinity of the 18 base pair distant site. This communication forms a toggle in which complete binding, i.e., the switch from “off” to “on”, is achieved within a narrow ComK concentration range.

 


Location: 

Carolyn Hoff Lynch Room

Chemistry Complex

 

Host:  Barry Cooperman

Jessica Anna Named Sloan Fellow

Jessica Anna, Assistant Professor of Chemistry and Elliman Faculty Fellow, has been named as a 2019 Sloan Research Fellow. These two-year fellowships are awarded yearly to 126 early-career scholars in recognition of distinguished performance and a unique potential to make substantial contributions to their field.

 

The full list of Sloan Research Fellows is here.

 

 

 

Alumni Reception at APS Meeting in Boston

Tue, 2019-03-05 18:00 - 20:00
Location: 

Tuesday, March 5, 2019

6:00 – 8:00 PM

 

The Westin Boston Waterfront

Room: Revere

425 Summer Street

Boston, MA 02210

617.532.4893

 

Please RSVP to alumni@chem.upenn.edu.

Attached Document: 

Department of Chemistry

231 S. 34 Street, Philadelphia, PA 19104-6323

215.898.8317 voice | 215.573.2112 fax | web@chem.upenn.edu

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