This course will provide an introduction of structure-property relationships in materials chemistry on length scales from atomic dimension up to the microscale and then draw on examples of Chemical design for "Energy and Environmental Sustainability." We will introduce the "12 Principles of Green Chemistry" and "12 Principles of Green Engineering" as a guide to modern materials chemistry design and follow a trajectory that proceeds with increasing length scales of ordering in the solid state. We will introduce techniques of x-ray, neutron, electron, and ion beam based scattering, real space imaging and spectroscopies and use these to explore non-crystalline materials (amorphous, glasses, and time permitting quasicrystals and aperiodic systems) and crystalline solids. Studies will proceed from atomic scales through nanoscale, mesoscale, and micro-scale discussing the emergence of band structure and delcocalized electronic and optical properties that emerge due to the finite scale of ordering and influence of the surface. Select examples will be drawn from advances in materials for in solar energy utilization with photochemistry and photoelectrochemistry and materials for photovoltaic and enabling advances electrochemical energy conversion and storage.

Continuation of X-ray I course, CHEM 741

An introduction to the theory and practice of structure determination by X-ray crystallography. Topics discussed include point group and space group symmetry, structure factor theory, data collection methods and a survey of solution methods. The course culminates with a series of real-world structure determinations worked through in-class using the XSeed program package.

This course focuses on current topics in Chemical Biology, particularly experiments in which 1) chemical synthesis enables one to probe or control biological systems, or 2) manipulation of biological systems facilitates novel chemical syntheses. The course is broadly divided into two sections, one dealing with the study of individual proteins and nucleic acids, and one dealing with complex cellular systems. As the goal of the course is to familiarize students with innovative recent experimental approaches and to stimulate them to conceive of their own new methodology, students will be responsible for delivering presentations on topics selected from the literature, designing experiments to address currently unsolved problems in Chemical Biology (in take-home examinations), and generating several novel research proposal ideas, one of which will be elaborated into a full proposal.

This course will include a review of basic reaction mechanisms, stereoelectronic effects, functional groups and acid-base chemistry. The course will emphasize the writing of mechanisms using the curved-arrow notation and organic reactions. Bonding and electronic structure theories and more involved mechanisms will be discussed. Students are expected to have a good working knowledge of reactions, functional groups, stereochemistry and mechanisms from undergraduate organic chemistry. Students will be expected to review basic concepts in Organic Chemistry and spectroscopy. The course will include lectures and recitations, and students are expected to attend and participate.

This course will include a review of basic reaction mechanisms, stereoelectronic effects, functional groups and acid-base chemistry. The course will emphasize the writing of mechanisms using the curved-arrow notation and organic reactions. Bonding and electronic structure theories and more involved mechanisms will be discussed. Students are expected to have a good working knowledge of reactions, functional groups, stereochemistry and mechanisms from undergraduate organic chemistry. Students will be expected to review basic concepts in Organic Chemistry and spectroscopy. The course will include lectures and recitations, and students are expected to attend and participate.

The focus of this course comprise the development of two synthetic strategies to access architecturally complex natural products of biological significance exploiting innovative chemistry. Lectures towards this end are given. As a project, each studnet is given a different complex natural product and expected at the end of the course to deveop two strategies, one based on asymmetric induction to provide the absolute stereochemical structure, the second where the absolute stereochemistry derives from commercially available starting materials.

This course focuses on concepts and strategies in medicinal chemistry, and how it is applied to modern drug discovery and development. Topics include the drug discovery process, drug targets (GRCR?s, enzymes, channels etc.), physical chemistry of molecular interactions between drug and target, drug design, methods for hit and lead identification, lead optimization, chemical biology, natural products chemistry and combinatorial and diversity oriented synthesis. This course is geared to upper level undergraduate students in chemistry or biochemistry, and first year chemistry graduate students. A strong understanding of organic chemistry is required.

The course will cover Nuclear Magnetic Resonance (NMR) theory at a level appropriate for graduate students in Organic Chemistry. It will also provide hands-on practical training in the correct use of high-field NMR spectrometers. Organic Spectroscopic methods for the determination of structure using NMR will be stressed. Permission of instructor required.

This course, for graduate students, encompasses topics in fundamental and applied photochemistry and photophysics from the fields of organic chemistry and chemical biology. Key topics and concepts will include basic photophysics, interactions of light with matter, UV-Vis absorption and emission spectroscopy, energy transfer, kinetics/dynamics, Jablonski diagrams, electron transfer, organic photochemistry, and applications in organic chemistry and chemical biology. These topics and concepts will be covered in the context of frontier applications including synthetic chemistry organic photochemistry, molecular imaging, and optogenetic tools among others.