Sergei Vinogradov

Photo: 
First Name: 
Sergei
Last Name: 
Vinogradov
Official Title: 
Associate Professor of Biochemistry and Biophysics

Biophysical Chemistry, Photochemistry/Photophysics

Contact Information
Email: 
VINOGRAD@MAIL.MED.UPENN.EDU
Phone: 
215-573-7524
Education: 

M.S. (Chemistry) Moscow State University, Russia, 1988.

Ph.D. (Organic Chemistry) Moscow State University, Russia, 1995.

Research Interests: 
Dr. Vinogradov's research is focused on the development of advanced probes for microscopy and imaging applications. On the fundamental level our interests encompass chemistry of porphyrins and other pyrrolic dyes, energy and electron transfer in multichromophoric systems, spectroscopy and imaging. Essentially, we are a group of synthetic and physical chemists developing new techniques for biomedical research. Over the past years the main focus of the lab has been optical imaging of oxygen in biological systems, including chemistry of imaging probes, phosphorescence lifetime imaging instrumentation, image reconstruction methods and a variety of applications of phosphorescence. Other bio-analytes of interests have been pH and metal ions. Currently the laboratory also pursues interests in optical energy upconversion and magnetic field effects on luminescence in view of their applications in imaging. Dr. Vinogradov collaborates broadly with laboratories across the world whose interests include basic studies of cellular metabolism and applications in neuroscience, stem cell biology, cancer therapy, tissue engineering and ophthalmology.
Selected Publications: 

Esipova, T. V., Ye, X. C., Collins, J. E., Sakadzic, S., Mandeville, E. T., Murray, C. B., Vinogradov, S. A.: Dendritic upconverting nanoparticles enable in vivo multiphoton microscopy with low-power continuous wave sources. PNAS 109(51): 20826-20831, 2012.

 

Mani, T., Tanabe, M., Yamauchi, S., Tkachenko, N. V., Vinogradov, S. A.: Modulation of Visible Room Temperature Phosphorescence by Weak Magnetic Fields. Journal of Physical Chemistry Letters 3(21): 3115-3119, 2012.

 

Mani, T., Niedzwiedzki, D.M., Vinogradov, S.A.: Generation of Phosphorescent Triplet States via Photoinduced Electron Transfer: Energy and Electron Transfer Dynamics in Pt Porphyrin-Rhodamine B Dyads. J. Phys. Chem. A. 116: 3598−3610, 2012.

 

Vinogradov, S.A., Wilson, D.F. : Porphyrin-dendrimers as biological oxygen sensors. Designing dendrimers. Wiley, 2012.

 

Esipova, T. V., Karagodov, A., Miller, J., Wilson, D. F., Busch, T. M., Vinogradov, S. A.: Two new "protected" oxyphors for biological oximetry: properties and application in tumor imaging. Analytical Chemistry 83(22): 8756-8765, 2011.

 

Lecoq, J., Parpaleix, A., Roussakis, E., Ducros, M., Houssen, Y. G., Vinogradov, S. A.*, Charpak, S.*: Simultaneous two-photon imaging of oxygen and blood flow in deep cerebral vessels. Nature Medicine 17(7): 893-U262, 2011 Notes: Note that postdoc E. Roussakis is a co-first author and I am one of the two senior corresponding authors. My lab is entirely responsible for the new oxygen microscopy technology and worked with the collaborator to implement it in the brain.

 

Finikova, O. S., Lebedev, A. Y., Aprelev, A., Troxler, T., Gao, F., Garnacho, C., Muro, S., Hochstrasser, R. M., Vinogradov, S. A.: Oxygen microscopy by two-photon-excited phosphorescence. ChemPhysChem 9(12): 1673-1679, 2008.

 

Apreleva, S. V., Wilson, D. F., Vinogradov, S. A.: Tomographic imaging of oxygen by phosphorescence lifetime. Applied Optics 45(33): 8547-8559, 2006.

Mid-Atlantic Seaboard Inorganic Symposium (MASIS) 2016

Wed, 2016-07-20 09:00 - 20:00

Mid-Atlantic Seaboard Inorganic Symposium (MASIS) 2016

Wednesday, July 20

Seminars held at Stiteler Hall (Rm. B6); poster session in Chem ‘73 Bldg., Nobel Hall

 

9:00 – 10:00         Registration, Department of Chemistry’s Chem ’73 Bldg., Nobel Hall  (REGISTRATION REQUIRED)

 

Making Conferences Work For You

Mon, 2016-07-18 14:00 - 15:00

Tools for ACS and Beyond

 

Location: IAST 2000

 

Panelists:

Prof. Elizabeth Rhodes

Prof. Neil Tomson

Prof. James Petersson

Geraint Davies

 

Moderator: 

Judith Currano

 

Coffee and donuts will be served!

Andrew Rappe Named to Endowed Chair

Andrew M. Rappe has been appointed as the Blanchard Professor of Chemistry. This Professorship, previously held by Larry Sneddon, was endowed in 1907 and the first Blanchard Professor was University Provost (and ACS President) Edgar Fahs Smith.

Janice Brochetti

Photo: 
First Name: 
Janice
Last Name: 
Brochetti
Official Title: 
Grants Manager
Contact Information
Office Location: 
Room 124, 1973 Building
Email: 
janbro@sas.upenn.edu
Phone: 
215-898-8300

Inorganic Chemistry Seminar (Stosh Kozimor, Los Alamos National Laboratory) CANCELED

Tue, 2017-04-18 12:00 - 13:00
Location: 

Lynch Lecture Hall Chemistry Complex

Seminar has been canceled . Reschedule date TBA

Organic Chemistry Seminar (Mark Gandelman, Technion, Israel)

Mon, 2017-04-17 12:00 - 13:00
Speaker: 
"The lecture will consist of two parts. The first part will focus on chemistry of cationic nitrogen" "compounds. We will demonstrate that nitrenium cations, which are isostructural and isoelectronic to ubiquitous N-heterocyclic carbenes, can serve as ligands for a wide range of transition metals.1 It represents a missing link in the coordination behavior of carbenes and other main group carbene-like species. The chemistry of these systems and its relevance to catalysis will be discussed. Formation of a stable bond between the positively charged nitrenium ligands and cationic metal centers, providing an extremely rare example of cation-cation binding, will be also presented and discussed.2 In addition, we will disclose a first X-ray supported example of Lewis acids centered on nitrogen atom." "In a second part of the lecture, new efficient methods and reagents to the preparation of iodo-," "chloro-, bromo- and fluoroorganic compounds, as well as straightforward approach to the preparation of geminal dihaloalkanes, will be presented. We will demonstrate that the geminal dihaloalkanes have a great potential for facile functionalization to produce valuable complex organic compounds. Specifically, two new efficient catalytic methods utilizing geminal dihaloalkanes will be presented: (a) stereoconvergent enantioselective synthesis of tailor-made organic fluorides, which are difficult to prepare by other synthetic methods,3 and (b) enantio- and chemoselective assembly of tertiary" "stereocenters from the carboxylic acids just in few steps.4
Location: 

Lynch Lecture Hall Chemistry Complex

Attached Document: 

Inquires please contact Rosa Vargas at rvargas@sas.upenn.edu

Organic Chemistry Seminar (Paul Floreancig, University of Pittsburgh)

Mon, 2017-04-10 12:00 - 13:00
Speaker: 
"Natural Product Synthesis as an Entry to New Method Development and Biological Studies" The rigor of natural product synthesis continues to inspire new method development and to deliver compounds that provide insights into biological activity. This seminar will detail three studies that support this statement. Specifically, the talk will focus on 1) the extension of an approach to allylic alcohol transposition reaction to an efficient synthesis of the spliceosome inhibitor herboxidiene and an analog that provides insight into the biologically relevant conformation, 2) the advancement of unimolecular reactions that proceed through oxidative C–H functionalization to a bimolecular process for spiroacetal synthesis leading to the synthesis of the actin-binding cytotoxin bistramide A, and 3) the path from designing a multicomponent protocol for the synthesis of pederin and psymberin to understanding the structure-activity relationships of these compounds and a move into oxidative cargo release.
Location: 

Lynch Lecture Hall Chemistry Complex

Attached Document: 

Inquires please contact Rosa Vargas rvargas@sas.upenn.edu

Inorganic Chemistry Seminar (Kyle Lancaster, Cornell University)

Tue, 2017-02-28 12:00 - 13:00
Location: 

Lynch Lecture Hall Chemistry Complex

Inquires please contact Camille Pride at campride@sas.upenn.edu

Organic Chemistry Seminar (Qiu Wang, Duke University)

Mon, 2017-02-27 12:00 - 13:00
Location: 

Lynch Lecture Hall Chemistry Complex

Inquires please contact Camille Pride at campride@sas.upenn.edu

Department of Chemistry

231 S. 34 Street, Philadelphia, PA 19104-6323

215.898.8317 voice | 215.573.2112 fax | web@chem.upenn.edu

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