Biological Chemistry seminar: Karim-Jean Armache, New York University

December 06, 2018 - 03:00 PM
Speaker: 

Karim-Jean Armache

New York University School of Medicine

 

"Mechanistic studies of gene silencing complexes"

 

Gene silencing is conserved from yeast to humans, playing a crucial function in establishment, maintenance and propagation of distinct patterns of gene expression. This process plays an essential role in development and its dysregulation can cause diseases including cancer. In all eukaryotes, regulation of gene activity is directed by packaging of DNA into chromatin. The fundamental repeating unit of chromatin is the nucleosome that comprises ~146 base pairs of DNA wrapped around an octamer of histone proteins. The nucleosome is the platform upon which proteins and protein complexes assemble to regulate chromosomal transactions such as gene transcription. These complexes act in part by modifying and/or binding to specific histone modifications. We use biochemical, biophysical and structural approaches to understand the detailed mechanisms of gene silencing complexes, their interplay with posttranslational modifications of histones and their effect on higher-order chromatin structure.

Location: 

Carolyn Hoff Lynch Room

Department of Chemistry

231 S. 34 Street, Philadelphia, PA 19104-6323

215.898.8317 voice | 215.573.2112 fax | web@chem.upenn.edu