RESCHEDULED: Inorganic Chemistry Seminar: Dr. Markus Ribbe, UCI

September 18, 2018 - 12:00 PM - 01:00 PM

Dr. Markus Ribble

Seminar Rescheduled 5/7/2019


"Nitrogenase M-Cluster Assembly:"

"Tracing the ‘9th Sulfur’ of the Nitrogenase Cofactor via a Semi-Synthetic Approach"

"The  M-cluster  is  the  active  site  of  nitrogenase  that  contains  an  8Fe-core  assembled  via coupling and rearrangement  of  two [Fe4S4]  clusters  concomitant  with  the  insertion  of  an interstitial carbon and a ‘9th  sulfur’. Combining synthetic [Fe4S4] clusters with an assembly protein template, we show that sulfite gives rise to the ‘9th sulfur’ that is incorporated in the catalytically important belt region of the cofactor after the radical SAM-dependent carbide insertion and the concurrent 8Fe-core rearrangement have already taken place. This work provides a semi-synthetic tool for strategically labeling the cofactor—including its ‘9th  S’ in the belt region—for mechanistic investigations of nitrogenase while suggesting an interesting"
"link between nitrogen fixation and sulfite detoxification in diazotrophic organisms."


Carol Lynch Lecture Hall

Chemistry Complex

Attached Document: 

Host: Dr. Tomson


Department of Chemistry

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