Organic Chemistry Seminar Dr. Kevin Brown (Indiana University)

May 21, 2018 - 12:00 PM - 01:00 PM
Speaker: 
Host: Kozlowski
Location: 
Carol Lynch Lecture Hall Chemistry Complex
Attached Document: 

Metal Catalyzed Alkene Functionalization: An Approach Toward Stereospecific Cross-Coupling

 

Stereospecific cross-coupling of chiral alkyl metal intermediates is a recognized challenge in modern organic synthesis. Here an alternative strategy is presented in which a chiral alkyl metal is generated as a catalytic intermediate by boryl-metalation of an alkene.1-5 This method represents an attractive approach in chemical synthesis because two new bonds and two new stereocenters are generated in a single operation. In addition, due to the synthetic versatility of the carbon-boron bond, a variety of structures can be readily prepared, thus representing a general approach toward carbofunctionalization of alkenes. The scope, mechanistic details, and application to complex molecule synthesis will be discussed.

 

inquires Rosa M. Vargas rvargas@sas.upenn.edu

Department of Chemistry

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