Organic Chemsitry Seminar Dr. Corinne Gosmini,( University of Paris , ECOLE POLYTECHNIQUE)

August 18, 2017 - 12:00 PM - 01:00 PM
Carol Lynch Lecture Hall, Chemistry Complex

Title: Cobalt-catalyzed reductive cross-coupling reactions


Transition-metal-catalyzed C-C bond formation has become ubiquitous in organic synthesis. The role of Cobalt as a transition-metal catalyst for organic reactions has long been confined to cyclisation reactions, eg. [2+2+2] cyclisations or Pauson-Khand reaction. However, in the last few decades, a new type of reactivity was discovered for cobalt salts, in carbon-carbon bond forming reactions. Our group in particular used cobalt for a variety of reactions, from arylzinc bromides synthesis to direct reductive cross-coupling reactions.

Although various strategies involving stoichiometric organometallic species are efficient and have been described since many years, versatile metal-catalyzed reductive cross-coupling reactions have recently appeared as an alternative to create operationally simple C-C bonds. Different metals such as Pd and mainly Ni have been used as catalyst. However, Cobalt salts also allow the reductive cross-couplings between two electrophiles and present the advantage to be cheaper and more environmentally friendly.  In such reactions, a catalytic cobalt organometallic reagent is generated under mild conditions thanks to different Co/Mn or Co/Zn systems.

In this presentation, several Co-catalyzed reductive cross-coupling reactions will be presented in order to form various C-C bonds from either alkyl, vinyl, (hetero)aryl or allyl compounds. A broad scope of functionalized substrates can be employed under mild conditions affording moderate to excellent yields.




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