Faculty

David M. Chenoweth

Photo: 
First Name: 
David M.
Last Name: 
Chenoweth
Official Title: 
Associate Professor of Chemistry

Organic and Bioorganic Chemistry

Contact Information
Office Location: 
2002 IAST, lab: 2020,2080,2100 IAST
Email: 
dcheno@sas.upenn.edu
Phone: 
215-­573-­1953
Admin Support: 
Education: 
  • B.S. Indiana University-Purdue University Indianapolis (1999)
  • Organic Chemist, Eli Lilly & Co., Indianapolis, IN (2000 – 2004)
  • Ph.D. California Institute of Technology (2009)
  • Kanel Foundation Predoctoral Fellow (2007 – 2009)
  • Caltech Herbert Newby McCoy Award (2009)
  • NIH/NIGMS Postdoctoral Fellow, Massachusetts Institute of Technology (2009 – 2010)
Research Interests: 

Research in the Chenoweth laboratory is grounded in organic chemistry and molecular recognition with applications to biological and materials problems. We synthesize molecules and study their properties and interactions for a broad range of applications in bioorganic and materials chemistry. We are particularly interested in the design and synthesis of new molecules that can modulate nucleic acid and protein structure. Additionally, we are equally interested in the synthesis of new materials with sensing and self-assembly properties.

 

Undergraduate students, graduate students, and postdoctoral researchers are exposed to a diverse array of topics including organic chemistry, synthesis, bioorganic chemistry, macromolecular structure (nucleic acids and proteins), biochemistry, and polymer chemistry.

Selected Publications: 

Zhang, Yitao; Malamakal, Roy M.; Chenoweth, David M. “Aza-Glycine Induces Collagen Hyperstability” J. Am. Chem. Soc. 2015, ASAP. DOI: 10.1021/jacs.5b04590. See Chemical & Engineering News story by Stu Borman: “Chemical Modification Is Best Ever At Strengthening And Stabilizing Collagen” Chemical & Engineering News, Volume 93, Issue 38, p. 7, News of The Week.

 

Zhang, Yitao; Malamakal, Roy M.; Chenoweth, David M. “A Single Stereodynamic Center Modulates the Rate of Self-Assembly in a Biomolecular System” Angew. Chem. Int. Ed. 2015, 54, 10826-10832.

 

Suh, Sung-Eun; Barros, Stephanie A.; Chenoweth, David M. “Triple Aryne–Tetrazine Reaction Enabling Rapid Access to a New Class of Polyaromatic Heterocycles” Chemical Science 2015, 6, 5128-5132.

 

Tran, Mai N.; Chenoweth, David M. “Synthesis and Properties of Lysosome-Specific Photoactivatable Probes for Live-Cell Imaging” Chemical Science 2015, 6, 4508-4512.

 

Barros, Stephanie A.; Chenoweth, David M. “Triptycene-Based Small Molecules Modulate (CAG)·(CTG) Repeat Junctions" Chemical Science 2015, 6, 4752-4755.

 

Tran, Mai N.; Chenoweth, David M. “Photoelectrocyclization as an Activation Mechanism for Organelle Specific Live-Cell Imaging Probes” Angew. Chem. Int. Ed. 2015, 54, 6442-6446.

 

Ballister, Edward R.; Ayloo, Swathi; Chenoweth, David M.; Lampson, Michael A.; Holzbaur, Erika L.F. “Optogenetic Control of Organelle Transport Using a Photocaged Chemical Inducer of Dimerization” Current Biology 2015, 10, R407-R408.

 

Ballister, Edward R.; Aonbangkhen, Chanat; Mayo, Alyssa M.; Lampson, Michael A.; Chenoweth, David M. "Localized Light-Induced Protein Dimerization in Living Cells using a Photocaged Dimerizer” Nature Communications 2014, 5, 5475.

 

Barros, Stephanie A.; Chenoweth, David M. "Recognition of Nucleic Acid Junctions Using Triptycene-Based Molecules” Angew. Chem. Int. Ed. 2014, 53, 13746-13750.

 

Rarig, Robert-André F.; Tran, Mai N.; Chenoweth, David M. "Synthesis and Conformational Dynamics of the Reported Structure of Xylopyridine A” J. Am. Chem. Soc. 2013, 135, 9213–9219, ASAP.

 

Chenoweth, David M.; Meier, Jordan L.; Dervan, Peter B. "Pyrrole-Imidazole Polyamides Distinguish Between Double-Helical DNA and RNA” Angew. Chem. Int. Ed. 2013, 52, 415-418.

 

Weizmann, Yossi; Chenoweth, David M.; Swager, Timothy, M. "DNA−CNT Nanowire Networks for DNA Detection” J. Am. Chem. Soc. 2011, 133, 3238–3241.

 

Chenoweth, David M.; Dervan, Peter B. “Structural Basis for Cyclic Py-Im Polyamide Allosteric Inhibition of Nuclear Receptor Binding” J. Am. Chem. Soc. 2010, 132, 14521. Selected for the cover of JACS Oct. 20, 2010, Vol 132, Issue 41. Covered by Chemical and Engineering News Sept. 27, 2010 issue, “Putting DNA in a Bind”.

 

Weizmann, Yossi; Chenoweth, David M.; Swager, Timothy, M. “Addressable Terminally-Linked DNA-CNT Nanowires” J. Am. Chem. Soc. 2010, 132, 14009.

 

Weizmann, Yossi; Lim, Jeewoo; Chenoweth, David M.; Swager, Timothy, M. “Regiospecific Synthesis of Au-Nanorod/SWCNT/Au-Nanorod Heterojunctions” Nano Lett. 2010, 10, 2466.

 

Chenoweth, Kimberly; Chenoweth, David M.; Goddard III, William A. “Cyclooctyne-based Reagents for Uncatalyzed Click Chemistry: A Computational Survey” Org. Biomol. Chem. 2009, 7, 5255.

 

Chenoweth, David M.; Harki, Daniel A.; Dervan, Peter B. “Oligomerization Route to DNA Binding Py-Im Polyamide Macrocycles” Org. Lett. 2009, 11, 3590.

 

Chenoweth, David M.; Dervan, Peter B. “Allosteric Modulation of DNA by Small Molecules” Proc. Natl. Acad. Sci. U.S.A. 2009, 106, 13175. Covered by Nature News: "Get into the groove" Nature 2009, 460, 669. Also selected by the Stanford Synchrotron (SSRL) as a science highlight for November 2009.

 

Chenoweth, David M.; Harki, Daniel A.; Dervan, Peter B. “Solution-Phase Synthesis of Pyrrole-Imidazole Polyamides” J. Am. Chem. Soc. 2009, 131, 7175.

 

Chenoweth, David M.; Harki, Daniel A.; Phillips, John W.; Dose, Christian; Dervan, Peter B. “Cyclic Pyrrole-Imidazole Polyamides Targeted to the Androgen Response Element” J. Am. Chem. Soc. 2009, 131, 7182.

 

Chenoweth, David M.; Chenoweth, Kimberly; Goddard III, William A. “Lancifodilactone G: Insights about an Unusually Stable Enol” J. Org. Chem., 2008, 73, 6853.

 

Dose, Christian; Farkas, Michelle E.; Chenoweth, David M.; Dervan, Peter B. “Next Generation Hairpin Polyamides with (R)-3,4-Diaminobutyric Acid Turn Unit” J. Am. Chem. Soc., 2008, 130, 6859.

 

Chenoweth, David M.; Viger, Anne; Dervan, Peter B. “Fluorescent Sequence-Specific dsDNA Binding Oligomers” J. Am. Chem. Soc., 2007, 129, 2216. Covered by Chemical and Engineering News.

 

Chenoweth, David M.; Poposki, Julie A.; Marques, Michael A.; Dervan, Peter B. “Programmable oligomers targeting 5'-GGGG-3' in the minor groove of DNA and NF-k B binding inhibition” Bioorg. Med. Chem., 2007, 15, 759.

 

Doss, Raymond M.; Marques, Michael M.; Foister, Shane; Chenoweth, David M.; Dervan, Peter B. “Programmable Oligomers for Minor Groove DNA Recognition” J. Am. Chem. Soc., 2006, 128, 9074.

 

Nurok, D.; Frost, M. C.; Chenoweth, D. M. “Separation using planar chromatography with electroosmotic flow” J. Chromatogr., A, 2000, 903, 211. 

 

Nurok, David; Frost, Megan C.; Pritchard, Cary L.; Chenoweth, David M. “The performance of planar chromatography using electroosmotic flow” J. Planar Chromatogr.-Mod. TLC, 1998, 11, 244.

Donald H. Berry

Photo: 
First Name: 
Donald H.
Last Name: 
Berry
Official Title: 
Professor of Chemistry

Inorganic and Organometallic Chemistry

Research Statement

Our research group is concerned with synthesis, structure and mechanism in inorganic and organometallic systems. We are interested in the preparation and study of new organometallic compounds which pose significant questions of structure and bonding, or which are designed to exhibit unusual reactivity in chemical transformations. We are also developing new synthetic routes to inorganic and organometallic polymers. General areas of interest are described below:

 

Contact Information
Office Location: 
554 N
Email: 
berry@sas.upenn.edu
Phone: 
(215) 898-2705
Admin Support: 
Education: 
  • S.B. Massachusetts Institute of Technology (1979)
  • Ph.D. California Institute of Technology (1984)
  • Research Associate, University of Rochester (1985)
  • Alfred P. Sloan Research Fellow (1990)
  • Chair, Chemistry Undergraduate Committee (2000- )
Selected Publications: 

 

"Evidence for Ligand Non-Innocence in a Formally Ruthenium(I) Hydride Complex," Noah L. Wieder, Michelle Gallagher, Patrick J. Carroll, and Donald H. Berry* J. Am. Chem. Soc. 2010, 132, 4107-4109.

 

"Low-Valent Ruthenium Complexes of the Non-innocent 2,6-Bis(imino)pyridine Ligand" Michelle Gallagher, Noah L. Wieder, Vladimir K. Dioumaev, Patrick J. Carroll, and Donald H. Berry* Organometallics, 2010, 29,591-603.

 

D. A. Ruddy, D. H. Berry, and C. Nataro, “Synthesis and characterization of 1-methyl-1-silaindane and 1-methyl-1-germaindane,” J. Organomet. Chem. 2008, 693, 169-172.

 

H. Yoo, P. J. Carroll, and D. H. Berry, “Synthesis and Structure of Ruthenium-Silylene Complexes: Activation of Si-Cl Bonds in N-Heterocyclic Silanes,” J. Amer. Chem. Soc. 2006, 128, 6038-6039. 

 

Y. Huo and D. H. Berry, "Synthesis and Properties of Hybrid Organic-Inorganic Materials Containing Covalently Bonded Luminescent Polygermanes," Chem. Mat., 2005, 17, 157-163.

 

B. Arkles, Y. Pan, G.L. Larson, and D. H. Berry, "Cyclic Azasilanes: Volatile Coupling Agents for Nanotechnology," Silanes and Other Coupling Agents, Vol 3, K.L. Mittal, ed. 2004,.

 

V. K. Dioumaev, L. J. Procopio, P. J. Carroll, and D. H. Berry, "Synthesis and Reactivity of Silyl Ruthenium Complexes: The Importance of Trans Effects in C-H Activation, Si-C Bond Formation, and Dehydrogenative Coupling of Silanes," J. Am. Chem. Soc. 2003, 125, 8043-8058.

 

V. K. Dioumaev, B. R. Yoo, P. J. Carroll, and D. H. Berry "Structure and Reactivity of Bis(Silyl) Dihydride Complexes (PMe3)3Ru(SiR3)2H2: Model Compounds and Real Intermediates in a Dehydrogenative C-Si Bond Forming Reactions," J. Am. Chem. Soc. 2003, 125, 8936-8948.

 

V. K. Dioumaev, P. J. Carroll, and D. H. Berry "Tandem ?-CH Activation / SiH Elimination Reactions: Stabilization of CH Activation Products by beta-Agostic SiH Interactions, " Angew. Chem. Int. Ed. Engl. 2003, 42, 3947-3949.

 

M. Motonaga, H. Nakashima, S. M. Katz, D. H. Berry, T. Imase, S. Kawauchi, M. Fujiki, and J. R. Koe, "The First Optically Active Polygermanes: Preferential Screw Sense Helicity of Enantiopure Chiral-substituted Aryl Polygermanes and Comparison with Analogous Polysilanes," J. Organomet. Chem. 2003, 685, 44-50.

 

K. A. Ezbiansky, D. H. Berry, B. Arkles, and R. J. Composto, Fluoride-Catalyzed Conversion of b-AcetoxyEthyl-Silsesquioxane: a Chloride-Free Pre-cursor for Silica Films", Polym. Prepr., 2001, 42, 101-102.

 

K. A. Ezbiansky, B. Arkles, R. J. Composto, and D. H. Berry, "b-Acetoxyethyl Silsesquioxanes: Chloride-Free Pre-cursors For SiO2 Films Via Staged Hydrolysis," Mater. Res. Soc. Symp. Proc., 2000, 606, 251-256.

 

V. K. Dioumaev, K. Plössl, P. J. Carroll, and D. H. Berry, "Access to Unsaturated Ruthenium Complexes via Phosphine Complexation with Triphenylborane; Synthesis and Structure of a Zwitterionic Arene Complex, (h6-Ph-BPh2H) Ru(PMe3)2(SiMe3).", Organometallics, 2000, 19, 3374-3378.

 

V. K. Dioumaev, K. Plössl, and D. H. Berry, "Formation and Interconversion of Ruthenium-Silene and 16-Electron Ruthenium Silyl Complexes," J. Am. Chem. Soc., 1999, 121, 8391-8392.

 

J. A. Reichl and D. H. Berry "Recent Progress in Transition Metal-Catalyzed Reactions of the Silicon, Germanium, and Tin," Adv. in Organomet. Chem., 1999, 43, 197-265.

 

K. A. Ezbiansky, P. I. Djurovich, M. LaForest, D. J. Sinning, R. Zayes, and D. H. Berry, "Catalytic C-H Bond Functionalization: Synthesis of Aryl-silanes by Dehydrogenative Transfer Coupling of Arenes and Triethylsilane," Organometallics, 1998, 17, 1455-1457.

 

S. M. Katz, J. A. Reichl, and D. H. Berry, "Catalytic Synthesis of Poly-(arylmethylgermanes) by Demethanative Coupling: A Mild Route to s-Conjugated Polymers," J. Am. Chem. Soc., 1998, 120, 9844-9855.

 

L. J. Procopio, P. J. Carroll, and D. H. Berry, "Structure and Reactivity of Cp2Zr(h2-Me2Si=NtBu)(CO): An Unusual Silanimine Carbonyl Complex with Extensive s-p* Back-Bonding," Polyhedron, 1995, 14, 45-55.

Tobias Baumgart

Photo: 
First Name: 
Tobias
Last Name: 
Baumgart
Official Title: 
Professor of Chemistry

Physical and Biological Chemistry

Additional Titles: 
Graduate Chair
Contact Information
Office Location: 
250 Chemistry Bldg.
Email: 
baumgart@sas.upenn.edu
Phone: 
215.573.7539
Fax: 
215.898.6242
Admin Support: 
Education: 

• Postdoctoral associate with Prof. Watt Webb at Cornell University (2001 – 2005)

 

• PhD from Max Planck Institute for Polymer Research and Johannes Gutenberg University of Mainz (2001)

 

• Diploma in Chemistry from the University of Clausthal, Germany (1998)

Research Interests: 

Research in the Baumgart group is largely centered on the physical chemistry of amphiphile membranes with lateral heterogeneity resulting from non-ideal mixing. Our aims include characterization of biologically relevant membranes including lipids and proteins, where we investigate both composition and shape (curvature) heterogeneity. Both of these aspects are thought to be highly relevant to the function of biological membranes. We focus on freely suspended, rather than solid supported membranes, with an emphasis on bilayer membranes, but we also include monolayer systems. We investigate membranes that laterally segregate into co-existing fluid phases, and are particularly interested in quantitatively understanding the phenomenon of line tension at the phase boundary. We also examine molecular details that govern the partitioning of functionally relevant protein constructs between coexisting membrane phases and thereby aim to contribute to enhancing the biophysical understanding of transmembrane signal transduction, particularly in immune cells such as T-cells, B-cells and mast cells. Our research on aspects of membrane shape is directed at understanding how molecules sort in membrane curvature gradients. This curvature sorting likely contributes substantially to intracellular membrane sorting and trafficking. Furthermore we have recently begun to investigate phase coexistence in binary mixtures of amphiphilic di-block copolymers. Finally, we develop methods to pattern cellular signaling ligands, such as antibodies and adhesion molecules, on pattern scales both above and below optical resolution.

Selected Publications: 

31) Heinrich, M., Tian A.,Esposito C., Baumgart T. (2010). Dynamic sorting of lipids and proteins by membrane curvature: a moving phase boundary problem. Proceedings of the National Academy of Sciences. In Print.

30) Johnson, S., Stinson, B., Reminik, J., Go, M., Fang, X., & Baumgart, T. (2010). Temperature dependent phase behavior and protein partitioning in giant plasma membrane vesicles. Biochimica et Biophysica Acta - Biomembranes. In Print.

29) Capraro, B. R., Yoon, Y., Cho, W., Baumgart, T. (2010). Curvature sensing by the epsin N-terminal homology (ENTH) domain measured on cylindrical lipid membrane tethers. Journal of the American Chemical Society, 132 (4), 1200-1201.

28) Levental, I., Byfield, F. J., Choudhourie, P., Madara, J., Gai, F., Baumgart, T., & Janmey P. A. (2009). Cholesterol-dependent phase separation in cell-derived giant plasma membrane vesicles. Biochemical Journal, 424 (2), 163-167.

27) Baker, R. G., Hsu, C. J., Lee, D., Jordan, M. S., Maltzman, J. S., Hammer, D. A., Baumgart, T., & Koretzky, G. A. (2009). The adapter protein SLP-76 mediates “outside-in” integrin signaling and function in T cells. Molecular and Cellular Biology, 29 (20), 5578-5589.

26) Christian, D., Tian, A., Ellenbroek, W., Levental, I., Rajagopal, K., Janmey, P., Liu, A., Baumgart, T., & Discher, D. (2009). Spotted vesicles, striped micelles and Janus assemblies induced by ligand binding. Nature Materials, 8, 843-849. DOI

25) Oh, H., Mohler III, E. R., Tian, A., Baumgart, T., & Diamond, S. L. (2009). Membrane cholesterol is a biomechanical regulator of neutrophil adhesion. Arteriosclerosis, Thrombosis, and Vascular Biology, 29, 1290-1297.

24) Tian, A., Capraro, B. R., Esposito, C., & Baumgart, T. (2009). Bending stiffness depends on curvature of ternary lipid mixture tubular membranes. Biophysical Journal, 97 (6), 1636-1646.

23) Das SL, Jenkins JT, Baumgart T. "Neck geometry and shape transitions in vesicles with co-existing fluid phases: Role of Gaussian curvature stiffness versus spontaneous curvature." Europhysics Letters, 2009, 86, 48003-48008.

22) Tian, A. and Baumgart, T. "Sorting of lipids and proteins in membrane curvature gradients." Biophysical Journal, 2009, 96, 2676-2688.

21) Das S., Tian A., Baumgart T., "Mechanical stability of micropipette aspirated giant vesicles with fluid phase coexistence." Journal of Physical Chemistry, B 2008, 112, 11625-11630.

20) Heinrich M.C., Levental I., Gelman H., Janmey P.A., Baumgart T. "Critical exponents for line tension and dipole density difference from lipid monolayer domain boundary fluctuations." Journal of Physical Chemistry, B 2008, 112, 8063-8068.

Department of Chemistry

231 S. 34 Street, Philadelphia, PA 19104-6323

215.898.8317 voice | 215.573.2112 fax | web@chem.upenn.edu

Syndicate content