Biological

Biological Chemistry seminar: David Chenoweth, University of Pennsylvania

Thu, 2018-12-13 15:00 - 16:00
Location: 

Carolyn Hoff Lynch Room

"Rational redesign of the collagen triple helix"

Biological Chemistry seminar: Alan Saghetalian, Salk Institute

Thu, 2019-03-14 15:00
Location: 
Carolyn Hoff Lynch Room

Topic:  New small biological molecules

Host:  Dr. Megan Matthews

Biological Chemistry seminar: Binghe Wang, Georgia State University

Thu, 2019-02-21 15:00
Location: 
Carolyn Hoff Lynch Room

Topic:  Drug design

Host:  Dr. Ivan Dmochowski

Biological Chemistry seminar: John Schneekloth, NIH

Thu, 2019-02-07 15:00
Location: 

Carolyn Hoff Lynch Room

Topic:  Small molecule probes of DNA, RNA, proteins

Host:  Dr. David Chenoweth

Biological Chemistry seminar: Amanda E. Hargrove, Duke University

Thu, 2019-01-24 15:00
Speaker: 

Amanda Hargrove

Duke University

 

"Deciphering patterns in selective small molecule:RNA interactions" While small molecules offer a unique opportunity to target structural and regulatory elements in therapeutically relevant RNAs, selectivity has been a recurrent challenge in small molecule:RNA recognition. In particular, RNAs tend to be more dynamic and offer less chemical functionality than proteins, and biologically active ligands must compete with the highly abundant and highly structured RNA of the ribosome. Indeed, no small molecule drugs targeting RNAs other than the ribosome are currently available, and our recent survey of the literature revealed little more than one hundred reported chemical probes that target non-ribosomal RNA in biological systems. As part of our efforts to improve small molecule targeting strategies and gain fundamental insights into small molecule:RNA recognition, we are analyzing patterns in both RNA-biased small molecule chemical space and RNA topological space privileged for differentiation. To begin, we identified physicochemical, structural, and spatial properties of biologically active RNA ligands that are distinct from those of protein-targeted ligands. Elaboration of four RNA binding scaffolds into a library enriched with these properties has led to improved recognition of medicinally relevant RNA targets, including viral and long noncoding RNA structures. At the same time, we used pattern recognition protocols to identify RNA topologies that can be differentially recognized by small molecules and have elaborated this technique to visualize conformational changes in RNA secondary structure. We are currently expanding these studies with the ultimate goal of applying these insights to the rapid development of ligands with high affinity and specificity for a wide range of RNA targets, particularly those critical to cancer progression.

Location: 

Carolyn Hoff Lynch Room

 

Host:  Dr. David Chenoweth

Biological Chemistry seminar: Jacob Hooker, Harvard University

Thu, 2019-01-17 15:00
Speaker: 

Jacob Hooker

Harvard Medical School

 

"Neurochemical imaging of the human brain with positron emission tomography"


Chemical reactions and interactions dominate human brain function, but unfortunately, we understand poorly the language of this chemical conversation going on in the brain. Although we have some sense for how neurochemicals communicate in cell culture, we have very littleunderstanding of the dynamic relationship between neurochemicals in the living human brain, whether it is at rest, being stimulated, or manipulated by drugs. Positron emission tomography (PET) provides a window into the human brain to study chemistry provided that a radiotracer can be developed to measure molecular interactions.  This seminar will describe the incredible opportunities in PET imaging and the tools that the Hooker Lab has codeveloped to better realize its full potential.


Location: 

Carolyn Hoff Lynch Room

Host: Dr. David Christianson

Biological Chemistry seminar: Karim-Jean Armache, New York University

Thu, 2018-12-06 15:00
Speaker: 

Karim-Jean Armache

New York University School of Medicine

 

"Mechanistic studies of gene silencing complexes"

 

Gene silencing is conserved from yeast to humans, playing a crucial function in establishment, maintenance and propagation of distinct patterns of gene expression. This process plays an essential role in development and its dysregulation can cause diseases including cancer. In all eukaryotes, regulation of gene activity is directed by packaging of DNA into chromatin. The fundamental repeating unit of chromatin is the nucleosome that comprises ~146 base pairs of DNA wrapped around an octamer of histone proteins. The nucleosome is the platform upon which proteins and protein complexes assemble to regulate chromosomal transactions such as gene transcription. These complexes act in part by modifying and/or binding to specific histone modifications. We use biochemical, biophysical and structural approaches to understand the detailed mechanisms of gene silencing complexes, their interplay with posttranslational modifications of histones and their effect on higher-order chromatin structure.

Location: 

Carolyn Hoff Lynch Room

Biological Chemistry seminar: Abhinav Nath, University of Washington

Thu, 2018-11-01 15:00
Location: 

Carolyn Hoff Lynch Room

Topic: Protein molecular dynamics and health

Host: Dr. Elizabeth Rhoades

Biological Chemistry seminar: Kabirul Islam, University of Pittsburgh

Thu, 2018-10-18 15:00
Location: 

Carolyn Hoff Lynch Room

"Protein and small molecule engineering towards an orthogonal chromatin landscape"

Host: Dr. E. James Petersson

Biological Chemistry seminar: Sua Myong, Johns Hopkins University

Thu, 2018-10-11 15:00
Location: 
Carolyn Hoff Lynch Room

"Defective RNA interaction leads to aberrant phase separation of ALS-linked mutant FUS"

Department of Chemistry

231 S. 34 Street, Philadelphia, PA 19104-6323

215.898.8317 voice | 215.573.2112 fax | web@chem.upenn.edu

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